Top 10 Best Prohormones: Strongest For Muscle Mass Gains And Cutting

By Nader Qudimat ·
Updated Jan 24, 2021



You’re here to make gains…

By now, you think you've tried everything.

You’re training hard, eating right, and it’s been ages since you’ve seen any real progress.

Now you probably have tried different things and taken your time to assess your past performance to improve future performance, and maybe even adjusted your diet as it may not be the best.

The last thing you want to do is go for a prohormone as that can get you on a path that can be very difficult to get off of.

And if you've considered SARMs then you know there's plenty of options to choose from before choosing the hardcore path of prohormones.

Prohormones can be very risky but the rewards can be amazing if it’s done right.

With the right stack, you can absolutely break through walls of plateau’s like never before.

But again, this category of supplements is only for those who really need to take their physiques to the next level.

Use a pre workout like Bulk to help with the gains.

Or try combining a testosterone booster for the ultimate muscle building stack. 

Assuming you know what you’re doing and have done your research, then go on and check out these top 10 prohormone supplements.

Otherwise, stick to a solid pre workout, maybe even consider a natural plant-based steroid supplement or our list for laxogenin before looking at these prohormones.

Remember, this category is very gray-area like, and it was hard enough to rank them in a top 10 style as they differ in strength and are not for everyone. 

Do your research and avoid these supplements if you are a beginner or under 22 years old and most importantly, ask your doctor and get approval before using any supplement.

You can also stack a prohormone supplement with a natural anabolic like Laxogenin and epicatechin. 

Make your own pre workout by buying from bulkstimulants like DMAA and DMHA.

Here are the top 10 prohormone supplements:

Best On-Cycle Support

When you're taking something as strong as these prohormones, it's recommended to use a on-cycle supplement for complete protection, as well as a PCT like this one.

Defend is an excellent choice as it contains 7 strong and fully dosed ingredients that will help protect and strengthen your organs.

It starts with a big 1 gram milk thistle extract and this ingredient has been used to protect against liver damage for years now.

The active ingredient here is Silymarin and it is an excellent antioxidant.

Various studies show it's protection against toxins in the liver and it's one of the ingredients that you should always see in a cycle support supplement.

Another crucial ingredient to have is NAC, N-Acetyl-Cysteine, which helps detoxify the liver and can even reverse and treat damage done to the liver. And some research shows it can also improve liver function.

The rest of the ingredients have various benefits from being anti inflammatory to helping aid stomach digestion and treat high cholesterol while improving the lipid profile.

Defend and it's profile of ingredients are important to have during a cycle.

Huge Nutrition is also a great source of supplements as their supplements are fully transparent, from their Wrecked pre workout to their plant-based natural steroid supplements.

They also have a PCT stack for optimal testosterone production and cycle support.

Use coupon code FITFREK for 10% off.

Or if you prefer to get cycle support from the UK, check out Cycle Guard Elite that contains similar ingredients. 



Top 10 Strongest Prohormone

1-AD is a 1-Andro (aka 1-DHEA) based prohormone produced by Hi Tech Pharmaceuticals.

1-Andro is one of the few prohormones that is not yet on the FDA’s banned list.

It is one of the most potent prohormones that are still legally available.

In one study, out of Texas A&M, consuming 330 mg of 1-Andro over 4 weeks had the same impact as a 300 mg cycle of injectable Testosterone.

1-AD includes 50 mg per serving of 5a Hydroxy Laxogenin Acetate.

This is a natural but powerful anabolic (aka nature's steroid!) which is derived from plants.

It assists in boosting mass and strength while also inhibiting cortisol levels.

Strength level: 8/10

Side effects: 6/10

So long as you are taking in plenty of quality protein and working out hard and smart, you will make pleasing mass gains on 1-AD.

However, this is a prohormone designed for experienced bodybuilders.

1-AD will aid as a cutting agent due to its ability to minimize cortisol levels while increasing lean muscle mass.



Blackstones Labs is a hardcore but trusted company that makes next level supplements.

Brutal 4Ce, their 4-andro supplement, is a formula that contains three different types of 4-DHEA, and the absorption is increased with its liposomal delivery technology.

You get only about 65mg per capsule, but you're also getting 3 forms of 4-andro, which means it'll be more effective.

To get 325mg, you'd need to take at least 5 capsules per day, split between the morning and evening.

This means you'll probably want to get more than one bottle for your cycle.

This is an effective prohormone to take and you can prevent side effects by taking in a proper on-cycle supplement.

Strength level: 8/10

Side effects: 6/10



Chosen 1 contains a 65mg blend of 1-DHEA.

1-DHEA is a precursor to 1-testosterone, a potent hormone that leads to more lean muscle gains and increased aggression in the gym. 

It's often compared to the banned compound epistane, making it a great choice for those living in the states if you can't get your hands on Havoc by RPN. 

Strength 7/10

Side effects 3/10

Users report more dry gains but with few side effects like headaches, increased anxiety, back pumps and testosterone suppression. 

Most of these can be prevented with a PCT supplement. 

It isn't toxic towards organs and it is legal as of today but we don't know how long that'll last. 



When it comes to hardcore supplements, like borderline legal, Hi-Tech Pharmaceuticals can be depended on. 

This prohormone, Decaboline 19-nor, is a derivative of Deca but has far less side effects, no water retention, and quick gains. 

Strength 8/10

Side effects 3/10

The downside is that there are some side effects but they are manageable with a PCT and / or on-cycle support supplements. 

Decabolin is the perfect choice for those bulking as it'll increase strength and gains at a incredible rate. 

It isn't unusual to hear of users making up to 10lbs of gains and massive improvements in strength. 

Some also report joint benefits, this might be due to the enhanced recovery that it provides. 

All in all, Decabolin 19-nor is a great choice for a prohormone. 



1-Testosterone is a muscle building prohormone that contains the highest level of 1-Andro of any product on the market.

1-Andro is a naturally occurring metabolite that is unable to convert to estrogen.

In a recent study, released in the Journal of Applied Physiology, 1-andro was as potent as testosterone enanthate, the gold standard for testosterone products.

In another study, out of West Texas A&M University, participants who were given 1-Andro gained an average lean mass of 10.4 pounds and an increase of 92.2 pounds in total load in the bench, squat and deadlift, the researchers concluded that the prohormone contributed to robust improvements in muscle mass and strength in resistance-trained individuals.

1-Testostosterone includes the Cyclosome Delivery System, which increases the bioavailability and effectiveness of prohormone compounds by undergoing cyclodextrin prior to lipid encapsulation.

This has been shown to improve bioavailability by an incredible 90%.

Reported side effects of this prohormone includes nausea, bloating and vomiting.

Strength level: 8/10

Side effects: 5/10

1-Testosterone has been shown to be 7 times more anabolic than testosterone.

It will lead to rapid increases in dry mass, that are sustainable after a cycle.

Because 1-Andro does not convert to estrogen, there is no problem with water retention when taking this product. Another upside is that it will also increase your fat burning capacity.

Another option is Metha Quad, a prohormone that contains 4 types of andro-based compounds, and it's a best seller.

Check it out here and use discount code FITFREK (15% off).

Use a PCT support like this one



Nano 1T is non-methylated and is claimed to be 7 times as anabolic as testosterone, making it an excellent prohormone.

It's neither hepatotoxic (harmful to liver) nor can it convert to estrogen or DHT.

The anabolic effects of Nano 1T is suppose to be better than most prohormones and with it not having any (if any) side effects like DHT, liver or estrogen issues, it really is an excellent choice.

The downside however is the taste and it can be reduced by having it mixed in a flavored drink.

Since there are no conversions to estrogen or stress on the liver.

Strength level: 8/10

Side effects: 3/10

Some users report up to 14-20lb gain on a 4-5 week cycle. That's incredible.

But the only reason why this isn't closer to Nanodrol is because of it's high price tag.

Having no side effects to liver or conversion to other hormones is a major advantage to Nano 1T, which is why it's definitely one of our recommended prohormones.

We still recommend using a PCT or an on-cycle support to ensure general health and optimal organ function.



Androtest is by Fusion Supplements, and it can be stacked with the top prohormone (Nanodrol).

It's a cyclodextrin complex of 4-androstenediol, meaning that it a one step prohormone to testosterone.

Each dose contains 25mg of 4-andro, making this a powerful muscle building stimulant.

The cyclodextrin enhances the bioavailability and absorption of the prohormone.

Androtest will provide more of the active prohormone 4-andro to convert directly to testosterone within your muscle cells.

Because this product has not been methylated it's relatively safe for your liver.

Androtest should be cycled on for 10 weeks before going off it for 8 weeks.

Do not exceed three cycles in a 12 month period.

Androtest should not be taken by women or guys under 21.

Strength level: 9/10

Side effects: 5/10

You will experience rapid muscle gains on Androtest, provided that you are training hard and fueling your muscles adequately.

Over the period of a 10 week cycle, you can expect gains of 6-8 pounds of lean muscle mass.

Androtest is a bulking agent.

Androtest has a one step conversion to testosterone which does aromatase.

You'll probably want to an aromatase inhibitor like Alchemy



Gaspari once had the crown for having the best prohormone back in 2005, but since then Halodrol has been reformulated to keep it legal. 

Hi-Tech has rebranded and reformulated Halodrol and turned it back into what was once known as a hard prohormone. 

Strength 9/10

Side effects 5/10

Halodrol packs 5 hardcore prohormones into a small package.

It has 1-andro, a prohormone that converts into testosterone. 

While it can improve body composition as one study shows, it can be a bit harsh on the organs. 

Next is 4-andro, also known as 4-AD, research shows it can increase testosterone, providing the body an anabolic environment for muscle growth but it does come with risk of increasing estrogen. 

Androsterone is pine pollen and it converts into DHT (dihydrotestosterone) and it's known to be more androgenic than testosterone. This will help with recovery and muscle growth but with the downside that comes with increased DHT levels is that it can cause baldness.

Use discount code FITFREK.



Havoc by RPN is a single ingredient prohormone.

It contains 2a, 3a-epithio-17a-methyl-5a-androstan-17b-ol, which is also known as Epistane.

This muscle building prohormone was released in 2007.

It has gained a reputation as a moderate ‘dry’ prohormone, which is not as ‘harsh’ as some others on the market.

As such, it is more ideally suited to beginner and intermediate bodybuilders.

Epistane is an anti-estrogenic prohormone, meaning that it will not aromatize.

It will boost the body’s natural production of testosterone, leading to more muscle mass, less fat and enhanced libido.

You will not experience an increase in water retention when taking Havoc.

Strength level: 8/10

Side effects: 4/10

Though your gains may not be as pronounced on Havoc as on some of the more extreme prohormones, you can expect to make substantial gains in lean mass, provided that you are training heavy and eating right.

If you are on a bulking diet, you can expect to gain 6-8 pounds of dry muscle, while also stripping off body fat over an 8-week cycle at 20-40 mg per day.

You should follow a post cycle therapy regime of 8 weeks.



Nanadrol is built around methylsternbolone, a DHT derived prohormone that has been proven to provide solid lean mass gains without water retention.

The methylsternbolone in Nanodrol has been broken down into particles that are less than 200nm in diameter.

This is a thousand times smaller than the methylsternbolone that is found in other products such as Ultradrol.

This makes it far faster absorbing and more bioavailable.

However Nanodrol does cause some stress to organs like Liver and we recommend using a PCT / on-cycle supplement. 

Strength level: 9/10

Side effects: 5/10

You will experience substantial strength and mass gains when supplementing with Nanodrol.

It can also be used in a recomp or cutting cycle.

After an 8-week cycle, you should follow a PCT cycle for another 8 weeks.

You should take an on-cycle support supplement for as much protection as possible.

Nanodrol is best taken while on a bulking diet, in which you are consuming excess clean calories.

On such a protocol, combined with hard out training, you may be able to gain up to 15 pounds in a 4 week cycle at 12 mg per dose.

For cycle support from the UK, get Cycle Guard Elite

Or a comprehensive (but expensive) supplement like this one works as well. 



14 thoughts on “Top 10 Best Prohormones: Strongest For Muscle Mass Gains And Cutting”

    • Hi Steve

      I don’t know personally, but there’s not much human research on Laxogenin supps.

      I would suggest going with Ep1logue, which has a similar profile but more reviews and I personally made some gains with it.

      Laxo is mainly hype so far, and Ep1logue is potent and lots of people are reporting gains with it.

  1. I jumped on a 4week cycle of nanodrol and all I can say is WOW!. Completely Savage man. After two weeks of use I packed on 20lbs of lean muscle. I’m rounding the final week of my month cycle ATM and just completely blown away by this product. I’m 37yo and have been lifting natural since 21.

    • Hey Robbie, it’s strong stuff! I’m impressed by your results. I know 10lbs would be lucky, but 20!

      Did you gain any fat along with the muscle? How much were you using and what sort of workouts were you doing?

        • Hi Brian, it’s recommended to take a cycle support supplement.

          Use a post cycle supplement. The number 1 prohormone, Nanodrol is methylated and it is taxing on the liver. So a on-cycle and post cycle supplement will do wonders in reducing the side effects.

          I also recommend joint support especially with something like Nanodrol.

          Stay safe!

  2. Hi guys,
    I am a recurring user of prohormones ( 10 cycles at least) and nanodrol is definitely not the best choice. I have made two cycles with this product, made some gains but nothing transcendent. And as a bonus this product is expensive. For me, the best prohormone is without a doubt our good old … Superdrol if we can tame the beast.
    Headaches due toblood pressure for 3/4 days, cramps (at least during the first cycle), lethargy (during the first cycle too). Need a high protein/high carb/ low fat diet, to supplement with coenzyme q10, red yeast rice, liv52, tudca, to make a good pct. But the gains are there and the product is not very expensive. Not for beginners. I still have to try the M1T which seems to be a killer.


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