DMAE and DMAA are two acronyms that sound similar but represent two very different substances.

This article will dive into the benefits, potential side effects, and comparisons of these substances.

Quick Summary: DMAE vs. DMAA At A Glance

DMAE (Dimethylaminoethanol): Found in various skincare products, DMAE has been studied for its potential mental health benefits.

DMAA (1,3-Dimethylamylamine): This dietary supplement ingredient is commonly used in sports nutrition products for its stimulant effects.

What Is DMAE?

Dimethylaminoethanol (DMAE) is known as a cognitive health compound.

It reduces the buildup of 'age pigment,' which impairs cognitive function and is linked to cognitive decline with age.

DMAE increases acetylcholine levels, which is crucial for memory improvement.

It has been shown to reduce beta-amyloid buildup, a compound associated with brain aging.

Uses Of DMAE

DMAE is studied for its potential benefits in both skincare and mental health.

DMAE In Skincare Products

DMAE is often used in skincare for its anti-aging benefits, helping to tighten and smooth the skin, thus reducing the appearance of fine lines and wrinkles.

DMAE For Mental Health Conditions

Beyond skincare, DMAE has been researched for its potential mental health benefits. Some studies suggest it may improve mood and mental clarity, making it relevant for conditions like depression, ADHD, Alzheimer's disease, and autism.

Benefits Of DMAE

• Memory Improvement: DMAE is included in many health supplements for its potential to enhance memory and cognitive abilities. A 2009 study demonstrated that mice with scopolamine-induced memory deficits showed significant improvement in memory and learning abilities after taking DMAE.
• Increased Physical Energy: Some users report increased physical stamina and endurance, although these effects are largely anecdotal.
• Improved Mood/Reduced Depression: DMAE may enhance mood by influencing neurotransmitters, with some users reporting improved well-being and reduced depressive symptoms.

Side Effects Of DMAE

Like any supplement, DMAE can have side effects, usually mild and self-resolving. Potential side effects include:

• Gastrointestinal Issues: Some users may experience constipation, bloating, or an upset stomach.
• Headaches: Mild headaches have been reported by some users.
• Insomnia: DMAE may cause difficulty sleeping, especially if taken later in the day.
• High Blood Pressure: There have been reports of increased blood pressure in some users. Individuals with high blood pressure or cardiovascular issues should consult a doctor before starting DMAE.

What Is DMAA?

DMAA, or 1,3-dimethylamylamine, is a potent central nervous system stimulant often found in pre-workout supplements and fat burners.

It's known for its ability to increase energy, focus, and endurance, making it a favorite among athletes and bodybuilders.

However, DMAA is not without its controversies. It has been linked to serious health risks, including heart attacks and strokes.

The FDA has issued warnings about its use, and it is banned in several countries.

You can read more about the safety, benefits, and side effects of DMAA here.

Recommended: FDA-Approved Safe Pre-Workouts

Benefits Of DMAA

The primary benefit of DMAA is its ability to enhance physical performance.

It does this by increasing the release of dopamine, a neurotransmitter that plays a key role in motivation, pleasure, and motor control.

This can lead to improved focus, energy, and endurance during workouts.

In addition to its performance-enhancing effects, DMAA can also aid in weight loss.

It has thermogenic properties, meaning it can increase your body's metabolism and fat-burning potential.

This makes it a popular ingredient in many fat burners.

However, it's important to note that while these benefits can be appealing, they come with significant risks.

The use of DMAA has been linked to serious health problems, including heart attacks and strokes.

As such, it should be used with caution and under the supervision of a healthcare professional.

Side Effects Of DMAA

While DMAA can provide significant performance-enhancing benefits, it also has many potential side effects. These can range from mild to severe and include:

• Increased Heart Rate and Blood Pressure: DMAA stimulates the nervous system, which can increase heart rate and blood pressure. This can be dangerous, particularly for individuals with pre-existing heart conditions.
• Nervousness and Anxiety: Some users feel jittery or anxious after taking DMAA, likely due to its stimulant effects.
• Difficulty Sleeping: DMAA can interfere with sleep patterns if taken later in the day because of its stimulant properties.
• Serious Health Risks: In some cases, DMAA use has been linked to severe health problems, including heart attacks and strokes. These risks appear to be higher in individuals with pre-existing health conditions and those who use DMAA in high doses or for extended periods.

It's important to note that while these side effects are potential risks, they do not occur in all users.

However, given the serious nature of some of these risks, it's recommended that DMAA be used with caution and under the supervision of a healthcare professional.

DMAE vs DMAA: A Comparative Analysis

While DMAE and DMAA may sound similar, they are very different substances with distinct uses, benefits, and risks.

Effectiveness And Potency

When it comes to effectiveness and potency, DMAA is often considered the stronger of the two.

Its stimulant properties provide significant boosts in energy and focus, which can enhance physical performance.

However, this increased potency also comes with higher risks and more severe side effects.

DMAE, on the other hand, is primarily known for its cognitive benefits.

It helps improve memory and mental clarity without the intense stimulant effects of DMAA.

This makes DMAE a safer option for those looking to enhance cognitive function without the risk of severe side effects.

Safety And Legal Status

In terms of safety and legal status, DMAE is generally considered safer and is legal in many countries.

It is widely used in both skincare products and supplements without major regulatory issues.

DMAA, however, has been associated with serious health risks, including heart attacks and strokes.

Due to these risks, the FDA has issued warnings against its use, and it is banned in several countries, including the United States.

Choosing Between DMAE And DMAA

The choice between DMAE and DMAA depends largely on individual needs and health status.

For those seeking cognitive benefits and improved mental clarity, DMAE is the preferred choice due to its safety and effectiveness in these areas.

However, for individuals looking for a potent stimulant to enhance physical performance, DMAA may be considered but should be used with extreme caution and under medical supervision.

FAQ

Here, we'll answer some of the most common questions about DMAE and DMAA, including their uses, benefits, side effects, and more.

What is the difference between DMAE and DMAA?

DMAE (Dimethylaminoethanol) is a precursor to the neurotransmitter acetylcholine and is known for supporting brain health and mood. DMAA (1,3-Dimethylamylamine) is a dietary supplement ingredient commonly used in sports nutrition products as a stimulant.

Is DMAE a stimulant like DMAA?

No, DMAE is known to support brain health and mood but does not act as a stimulant like DMAA.

What are the benefits of DMAE?

DMAE is believed to increase the production of acetylcholine, a compound involved in memory. It has also been studied for potential benefits in treating depression, ADHD, Alzheimer's disease, autism, and tardive dyskinesia.

What are the benefits of DMAA?

DMAA is used in sports nutrition products as a stimulant to promote focus and increase energy.

Are there any side effects of DMAE?

While DMAE is generally considered safe, some people may experience side effects such as constipation, itching, headache, drowsiness, insomnia, excitation, vivid dreams, confusion, depression, increased blood pressure, and exacerbation of schizophrenia symptoms, and unwanted movements of the face and mouth.

Are there any side effects of DMAA?

DMAA can potentially cause a range of side effects, including high blood pressure, shortness of breath, chest pain, stroke, and psychiatric disorders.

Can DMAE and DMAA be used together?

It's not recommended to use DMAE and DMAA together without the advice of a healthcare provider due to the potential for side effects and interactions.

What are some alternatives to DMAA?

There are several alternatives to DMAA that are safe, legal, and effective, including Teacrine, Dynamine, and Higenamine HCL.

Is DMAA banned?

Yes, DMAA has been banned by the FDA due to serious safety concerns.

What is DMHA and how does it compare to DMAA?

DMHA, like DMAA, is a stimulant and is found naturally in the bark of the walnut tree. Unlike DMAA, it is also manufactured synthetically.

Bottom Line: DMAE vs DMAA

DMAA is a powerful stimulant that can enhance physical performance and aid in weight loss.

However, it also comes with significant risks, including the potential for serious health problems like heart attacks and strokes.

On the other hand, DMAE is a nootropic compound used to enhance cognitive function.

It does not have the same stimulant effects as DMAA and is generally considered safer.

However, like any supplement, DMAE should be used responsibly.

Before starting any new supplement regimen, it's essential to research and understand the potential risks.

Consulting with a healthcare professional is always recommended.

References

1. Bloomer, R. J., Harvey, I. C., Farney, T. M., Bell, Z. W., & Canale, R. E. (2011). Effects of 1,3-dimethylamylamine and caffeine alone or in combination on heart rate and blood pressure in healthy men and women. Physician and sportsmedicine, 39(3), 111-120.
2. Cao, E., Chen, Y., Cui, Z., & Foster, D. O. (2012). Effect of dietary supplements containing 1,3-dimethylamylamine on systolic blood pressure in humans. AJP Heart and Circulatory Physiology, 303(11), H1298-H1304.
3. FDA. (2017). DMAA in Products Marketed as Dietary Supplements. U.S. Food and Drug Administration.
4. Hi-Tech Pharmaceuticals, Inc. v. FDA, No. 1:2013cv01747 - Document 133 (N.D. Ga. 2017). CourtListener.
5. Mimura, M., Ueki, M., Oku, H., Sato, B., & Ikeda, T. (2014). Effects of a supplement containing 1,3-dimethylamylamine on blood pressure and heart rate in healthy men and women. Clinical Ophthalmology, 8, 465-472.