GAIN MUSCLE

DMAA: Benefits, Side Effects, and Safety

by Nader Qudimat
Updated July 11, 2023

DMAA, also known as 1,3-dimethylamylamine, is a synthetic drug used in various dietary supplements for its potential benefits.

It was originally used as a nasal decongestant, but today, it's often found in products aimed at improving athletic performance, bodybuilding, and weight loss.

However, the use of DMAA is not without controversy due to potential side effects and safety concerns.

This article will discuss DMAA, its benefits, its side effects, and if it's worth using.

Let's get started...

DMAA: Quick Overview

DMAA is a synthetic drug that is often used in dietary supplements.

It's known for its stimulant effects, similar to decongestants like pseudoephedrine and ephedrine.

Some manufacturers claim that DMAA naturally comes from rose geranium oil, but laboratory analysis suggests this is false.

Instead, it appears that DMAA is artificially added to supplements.

Understanding DMAA

DMAA, or 1,3-dimethylamylamine, is a synthetic drug originally used as a nasal decongestant.

Today, it's often found in dietary supplements, particularly those aimed at improving athletic performance, bodybuilding, and weight loss.

How Does DMAA Work In The Body?

DMAA is thought to have stimulant effects similar to decongestants such as pseudoephedrine, ephedrine, and others.

Some promoters say that it is a safer alternative to ephedrine, but there is no scientific information to back up this claim.

What Does DMAA Do?

DMAA, also known as 1,3-dimethylamylamine, is a synthetic drug that has been widely used in dietary supplements, particularly those aimed at weight loss and bodybuilding.

It's known for its potent stimulant effects, which are often compared to those of other stimulants like caffeine and amphetamines.

Mechanism Of Action And Effects On The Body

DMAA works by increasing the release of norepinephrine, a neurotransmitter that plays a key role in the 'fight or flight' response.

This response triggers several physiological changes, such as increased heart rate, blood pressure, and blood glucose levels, which can enhance physical performance and fat burning.

In addition to its stimulant effects, DMAA has also been found to have cognitive-enhancing effects.

For instance, a study found that DMAA can improve short-term memory and reflexes, potentially making it a useful supplement for tasks that require mental alertness and quick reaction times.

Comparison To Other Stimulants

Compared to other stimulants, DMAA is often described as being more potent.

This is likely due to its ability to easily cross the blood-brain barrier, which allows it to exert its effects more directly on the central nervous system.

However, it's worth noting that the effects of DMAA can vary significantly between individuals, and some may be more sensitive to its effects than others.

Various Uses and Marketing As A "Legal High"

DMAA has been marketed in various forms, including as a standalone dietary supplement and an ingredient in pre-workout and weight-loss products.

It's often touted for enhancing physical performance, increasing weight loss, and improving mood and focus.

However, due to safety concerns, DMAA has been banned in many countries and by several sports authorities.

Despite this, it continues to be used illicitly by some individuals as a "legal high" due to its potent stimulant effects.

Legal Status Of DMAA In Different Countries

The legal status of DMAA varies by country.

In the United States, the Food and Drug Administration (FDA) has issued warnings about the safety of DMAA.

It has taken action to remove dietary supplements containing DMAA from the market.

Similarly, DMAA is classified as a prescription-only drug in the United Kingdom, making it illegal to sell without a prescription.

Ban By Sports Authorities

Several sports and anti-doping authorities, including the World Anti-Doping Agency and the National Collegiate Athletic Association, have banned DMAA due to its performance-enhancing effects and potential health risks.

The Benefits of DMAA

The benefits of DMAA are still being researched, and while some studies suggest potential benefits, more research is needed.

Some potential benefits that have been suggested include improved athletic performance and weight loss.

However, these benefits should be weighed against the potential risks and side effects associated with DMAA use.

Fat Burning

One of the main reasons DMAA is used in weight-loss supplements is its purported fat-burning effects.

Some research suggests that DMAA may increase metabolic rate and fat oxidation, which can contribute to weight loss.

However, more research is needed to confirm these effects and determine the optimal fat-burning dosage.

Effects on Short-Term Memory and Reflexes

In addition to its physical effects, DMAA may also have cognitive-enhancing effects.

A study found that DMAA improved short-term memory and reflexes in rats.

However, it's unclear whether these effects would also occur in humans, and more research is needed in this area.

Physical Performance

DMAA is often used in pre-workout supplements due to its purported performance-enhancing effects.

Some research suggests that DMAA may improve exercise performance by increasing power output and reducing perceived exertion.

However, more research is needed to confirm these effects and to determine the optimal dosage for performance enhancement.

How Long Does DMAA Stay In Your System?

DMAA's duration in the system can vary depending on several factors, including the individual's metabolism, the dosage taken, and whether it was combined with other substances.

However, some research suggests that DMAA can be detected in the urine for up to 24 hours after ingestion.

Typical Uses Of DMAA In Supplements

Many athletes take DMAA to improve performance.

However, DMAA was added to the World Anti-Doping Agency's prohibited substances list in 2010, so competitive athletes should avoid taking it.

Despite this, it's still commonly found in pre-workout supplements and other products to boost athletic performance.

The Side Effects Of DMAA

DMAA use is associated with many potential side effects, many of which can be severe.

These include liver damage, brain bleeding, increased heart rate and blood pressure, and nausea and vomiting.

DMAA can also interact negatively with certain enzymes and poses additional risks when combined with alcohol or caffeine.

Due to these potential risks, DMAA use is strongly discouraged. Study on DMAA side effects

Increased Heart Rate and Blood Pressure

DMAA is known to cause a significant increase in heart rate and blood pressure.

This is due to its stimulant properties, which can cause the heart to beat faster and the blood vessels to constrict, leading to increased blood pressure.

This can be particularly dangerous for individuals with pre-existing heart conditions or high blood pressure.

Increased heart rate and blood pressure

Liver Damage

There have been reports of DMAA causing severe liver damage in some individuals.

In these cases, individuals experienced symptoms such as jaundice, abdominal pain, and high levels of liver enzymes in the blood.

In some severe cases, individuals required a liver transplant. Liver damage

Brain Hemorrhage

In rare cases, DMAA has been linked to brain hemorrhages.

This is a serious condition where a blood vessel in the brain bursts, causing bleeding in the surrounding tissue.

This can lead to severe headaches, seizures, and in some cases, death. Brain hemorrhage

Nausea and Vomiting

Some individuals may experience gastrointestinal side effects such as nausea and vomiting when taking DMAA.

This can lead to dehydration and electrolyte imbalances if not properly managed.

Nausea and vomiting

Drug Interactions

DMAA can interact with other medications and substances, which can increase the risk of side effects.

For example, combining DMAA with alcohol or caffeine can increase the risk of cardiovascular side effects such as increased heart rate and blood pressure. Drug interactions

It's important to note that while these side effects have been reported, they are not guaranteed to occur in every individual who takes DMAA.

The risk of side effects can be influenced by various factors, including the individual's overall health, the dose of DMAA taken, and the use of other medications or substances.

Always consult with a healthcare provider before starting any new supplement regimen.

Safety Of DMAA

The safety of DMAA is a significant concern.

It has been removed from military stores in the US and banned in New Zealand.

The FDA considers supplements containing DMAA illegal, and its use has been linked to several reports of serious, life-threatening side effects.

DMAA in Pre-workout Supplements

Despite the potential risks, DMAA is still commonly found in pre-workout supplements.

These products often claim to boost energy, improve focus, and enhance athletic performance.

However, using these products cautiously is important due to the potential risks and side effects.

Abuse and Various Forms of DMAA

DMAA, due to its potent stimulant effects, has been subject to misuse and abuse.

Some individuals have used it to enhance athletic performance or cognitive function.

However, the misuse of DMAA can lead to a range of adverse effects, including cardiovascular complications and neurological symptoms. Research has highlighted the potential dangers associated with the misuse of DMAA.

Common Dietary Supplements Containing DMAA

Despite the risks and the regulatory actions taken against DMAA, it can still be found in some dietary supplements.

These products often market themselves as pre-workout supplements or weight loss aids.

However, consumers should know that DMAA-containing supplements can pose significant health risks.

Studies have shown that these supplements can cause a range of adverse effects.

Geranium Oil Extract?

There has been controversy surrounding the presence of DMAA in geranium oil extract.

Some manufacturers have claimed that DMAA is a natural constituent of geranium oil.

However, the FDA and independent research have found no credible scientific evidence to support this claim.

DMAA Dangers Compared To Other Questionable Substances

Compared to other controversial substances such as Adderall, ephedrine, and DMHA, DMAA presents a similar risk profile.

These substances act as potent stimulants and can lead to serious health complications if misused.

Research has highlighted the potential dangers associated with the use of these substances.

Dosage, Limitations, and Reviews

Although there isn't an established safe dosage for DMAA, acceptable doses can go up to 100mg.

Some supplements may use more but counter the side effects by using nitrates to enhance blood flow and vasodilation.

Also, the lack of comprehensive and unbiased research on DMAA presents a significant limitation.

User reviews on DMAA are mixed, with some users reporting positive experiences related to enhanced performance and others reporting adverse effects.

It's important to note that personal experiences can vary greatly and should not be used as a substitute for scientific evidence.

Studies have highlighted the need for further research into the effects and safety of DMAA.

FAQs

What is DMAA, and what does it do? DMAA, also known as 1,3-dimethylamylamine, is a synthetic drug that was once used in nasal decongestants. It's often found in dietary supplements, particularly those marketed for weight loss, bodybuilding, and performance enhancement. It works as a stimulant, increasing heart rate and blood pressure, and can lead to increased energy, focus, and stamina.

Is DMAA safe to use? The safety of DMAA is highly controversial. While some users report positive effects such as increased energy and focus, there are also numerous reports of serious side effects, including increased heart rate and blood pressure, liver damage, severe headaches, and even stroke. The FDA has issued warnings about the use of DMAA and it is banned in several countries.

What are the side effects of DMAA? Side effects of DMAA can include increased heart rate and blood pressure, liver damage, severe headaches, seizures, severe anxiety, mood changes, psychosis, risk of stroke, and in rare cases, sudden death.

Is DMAA illegal? The legal status of DMAA varies by country. In the United States, the FDA has issued warnings about DMAA, which is not allowed in dietary supplements. Many sports authorities also ban it due to its performance-enhancing effects.

Can DMAA help with weight loss? Some studies suggest that DMAA may help burn fat and increase body temperature, potentially aiding in weight loss. However, due to the potential for serious side effects, it is not recommended for this purpose without the supervision of a healthcare provider.

Does DMAA improve cognitive function? Some research suggests that DMAA may affect short-term memory and reflexes, potentially leading to improved cognitive function. However, more research is needed in this area.

How long does DMAA stay in your system? The exact length of time that DMAA stays in the system can vary based on several factors, including the specific dose taken and the individual's metabolism. However, it is known to be a relatively long-acting drug.

Can DMAA cause a positive drug test? Yes, DMAA can potentially cause a positive result on a drug test. It is structurally similar to amphetamines, commonly tested for in drug screens.

What are some common dietary supplements that contain DMAA? DMAA has been found in some dietary supplements, particularly those marketed for weight loss, bodybuilding, and performance enhancement. However, due to safety concerns and regulatory actions, its presence in these products is becoming less common.

Is DMAA found in geranium oil extract? There is controversy surrounding the presence of DMAA in geranium oil extract. Some manufacturers have claimed that their DMAA is derived from this source, but scientific analysis has not consistently supported these claims. The FDA states that DMAA is not a dietary ingredient and thus is not eligible for dietary supplements.

Bottom Line

While DMAA is often found in dietary supplements and is used by some athletes for its potential benefits, it's important to be aware of the potential risks and side effects.

The safety of DMAA is a significant concern, and its use has been linked to several serious, life-threatening side effects.

As such, it's important to use DMAA with caution and under the guidance of a healthcare professional.

by Nader Qudimat

Forged by iron and cold steel, I'm Nader, a mid-30s natural bodybuilder. Once a 100lb skinny guy, I've transformed into a 200lb muscular athlete with over 15 years of lifting experience. Today, I leverage my transformation and extensive experience to guide countless individuals on their fitness journeys.

Click here to check out my 12 year transformation: Natural 12 Year Transformation

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