How Much DMAA Is Safe?

by Nader Qudimat
Updated July 13, 2023

Determining the safe dosage of DMAA is tough due to the varying individual responses and potential health risks associated with its use.

The safety of DMAA is still a topic of ongoing research, and it's crucial to understand that what might be safe for one person could be harmful to another.

This article will explore the current scientific understanding of DMAA dosage, its effects, and safety considerations.

How Much DMAA Is Safe: Quick Rundown

Some manufacturers suggest a daily dosage of 10-20mg, while others recommend up to 70mg.

However, these are based on anecdotal reports and some pre-workouts can put higher dosages of DMAA if they combine it with nitric oxide boosters to reduce the cardiovascular strain that it may otherwise have.

Recommended Dosage

The recommended dosage of DMAA varies depending on the source. Some manufacturers suggest a daily dosage of 10-20mg, while others recommend up to 70mg in a day.

However, these recommendations are not based on rigorous scientific research and should be cautiously approached.

study on healthy men who took DMAA supplements daily for 12 weeks showed no significant changes in their health markers.

The participants in this study took 50mg of DMAA per day, either alone or in combination with 250mg of caffeine.

Dosage for Pre-Workout Supplements

  • Dosage: The typical dosage of DMAA in pre-workout supplements is between 25-75 mg.
  • Side Effects: At this dosage, side effects can include increased blood pressure, shortness of breath, chest pain, and risk of heart attack or stroke.

Dosage for Weight Loss Supplements

  • Dosage: DMAA is typically dosed at 25-75 mg in weight loss supplements.
  • Side Effects: At this dosage, side effects can include increased heart rate, high blood pressure, and risk of cardiovascular events.

Dosage for Energy Drinks

  • Dosage: DMAA is typically dosed at 10-20 mg in energy drinks.
  • Side Effects: At this dosage, side effects can include increased heart rate, high blood pressure, and risk of cardiovascular events.

Effects of DMAA on the Body

DMAA is a potent central nervous system stimulant that can increase heart rate and blood pressure.

A study on the effects of DMAA and caffeine on heart rate and blood pressure in healthy men and women found that the ingestion of DMAA, alone or in combination with caffeine, resulted in an increase in systolic blood pressure, diastolic blood pressure, and rate pressure product without an increase in heart rate.

The most significant increase was observed 60 minutes after ingesting 75mg of DMAA combined with 250mg of caffeine.

Let's explore the benefits, side effects, and risks below...


  • Energy Boost: DMAA is known to provide a significant energy boost, which can enhance workout performance and endurance.
  • Weight Loss: DMAA can aid in weight loss by suppressing appetite and increasing metabolism.
  • Improved Focus: DMAA can improve focus and concentration, benefiting workouts and cognitive tasks.

Side Effects

  • Cardiovascular Risks: DMAA can increase heart rate and blood pressure, leading to serious cardiovascular events such as heart attack or stroke.
  • Nervous System Effects: DMAA can cause nervousness, irritability, and tremors.
  • Gastrointestinal Issues: DMAA can cause nausea, vomiting, and other gastrointestinal issues.


  • Addiction: There is a risk of dependency on DMAA due to its stimulant properties.
  • Health Risks: Long-term use of DMAA can lead to serious health issues, including liver damage and cardiovascular disease.
  • Interactions: DMAA can interact with other medications and substances, increasing the risk of adverse effects.

Nitric Oxide Boosters (Nitrates)

Nitric oxide boosters, particularly nitrates, are becoming increasingly popular as a supplement for those looking to improve muscular performance and blood flow.

These nitrates are high in green leafy vegetables like spinach and arugula, and root vegetables like beets.

The biological effects of dietary nitrates are mediated through the nitrate-nitrite-nitric oxide pathway.

This pathway is generally efficient, but it's important to note that nitric oxide production can be attenuated by aging, lifestyle choices like smoking, and the use of antibacterial mouthwash which disrupts the commensal bacteria responsible for the reduction of nitrates to nitrites in the oral cavity source.

Benefits of Nitrates

Consumption of dietary nitrates in humans, most commonly in the form of concentrated beetroot juice, has significantly increased circulating nitrates and nitrites, with peak concentrations occurring at 2-3 hours post-consumption.

Studies implementing chronic consumption of whole-food nitrate sources have resulted in elevated plasma nitrate and nitrite concentrations, comparable to those utilizing beetroot juice source.

While the vasodilatory properties of nitrates have been widely documented, its effects on muscle oxygenation and blood flow during resistance exercise have been inconsistent.

Some studies have reported increased brachial artery blood flow and muscle oxygenation during handgrip exercise following nitrate doses.

However, not all studies agree, as some nitrate doses failed to alter muscle oxygenation following isotonic knee extensions and resulted in unaltered oxygenation of the anterior deltoid during a fatiguing bench press protocol source.

Dosages Used in Various Studies

The dosages of nitrates used in various studies vary greatly.

Some studies have used doses as low as 180 mg, while others have used as high as 400 mg.

The effects of these dosages on muscle oxygenation and blood flow during resistance exercise have been inconsistent, with some studies reporting increases in brachial artery blood flow and muscle oxygenation and others reporting no significant changes source.

Potential Side Effects

Nitrate supplements are generally well-tolerated, with minimal side effects reported.

However, athletes should be aware that beetroot juice, a common source of dietary nitrates, may induce beeturia.

In this harmless condition, urine and stool may turn red or pink after consuming beetroot or foods colored with beetroot extract source.

Combining Nitric Oxide with DMAA

Using nitric oxide boosters like arginine nitrate or beetroot is innovative because this can help reduce the side effects of DMAA.

You can find our list for the best nitric oxide boosters here.

That also explains how pre-workouts containing 120mg DMAA can get away without reported cases of harm as it uses nitrate-based ingredients to reduce the side effects.

Safety Considerations

While some studies suggest that certain dosages of DMAA may not result in significant health changes, it's essential to note that these studies are limited and do not account for long-term use or the potential for adverse reactions in individuals with pre-existing health conditions.

Furthermore, DMAA has been associated with serious health risks, including heart attacks and strokes, particularly when taken in high doses or combined with other stimulants like caffeine.

1,3-Dimethylamylamine (DMAA) is a compound that has gained popularity in the fitness industry, often found in pre-workout supplements and fat burners.

It's known for its powerful effects on energy levels and focus.

However, it's important to understand how DMAA works in the body and its potential effects on our health.

How DMAA Works

DMAA, or methylhexanamine, is a stimulant initially developed as a nasal decongestant.

It works by causing the body to release norepinephrine, a neurotransmitter that triggers the body's fight-or-flight response.

This can lead to increased heart rate and blood pressure.

DMAA And Dopamine

Dopamine is a neurotransmitter, a chemical messenger that transmits signals in the brain and other body areas.

It plays a significant role in how we feel pleasure and is also involved in our ability to think and plan. Dopamine can affect mood, motivation, and physical performance.

DMAA stimulates dopamine release, increasing levels of this neurotransmitter in the body.

This effect is supported by research that shows DMAA can enhance mood and motivation, which are heavily influenced by dopamine.

However, the impact of DMAA on dopamine can also have drawbacks, such as dependency and withdrawal symptoms.

DMAA As A Neurotransmitter Modulator

DMAA is believed to act as a neurotransmitter modulator.

It's thought to stimulate the release of norepinephrine, a neurotransmitter that plays a crucial role in attention and focus.

This action could indirectly influence dopamine levels.

Dopamine and norepinephrine are closely linked in the brain's reward system, and an increase in norepinephrine could potentially lead to an increase in dopamine, enhancing feelings of pleasure and reward.

DMAA As A Dopamine Reuptake Inhibitor

Another theory is that DMAA may act as a dopamine reuptake inhibitor.

This means that it could prevent the reabsorption of dopamine into neurons after it has transmitted a neural impulse.

This action would leave more dopamine in the synaptic gap, enhancing its effects.

However, this theory is yet to be confirmed by scientific research.

Safety And Legality Of DMAA

Due to safety concerns, DMAA is banned in several countries, including the US.

The FDA has issued warnings about DMAA, stating that it can increase blood pressure and lead to cardiovascular problems such as shortness of breath, arrhythmias, tightening in the chest, and even heart attack.

Dosage of DMAA

The typical dosage of DMAA in dietary supplements ranges from 25 to 75 mg per day.

This dosage is often split into several smaller doses throughout the day.

However, it's important to note that the safety and appropriate dosage of DMAA are subjects of ongoing debate.

For more detailed information, you can refer to these articles:


  • What is the safe dosage of DMAA? The safe dosage of DMAA varies among individuals. It's generally recommended to start with a low dose and gradually increase it under the supervision of a healthcare professional. However, due to potential health risks, DMAA is banned in many countries and not recommended for use.

  • Can DMAA cause serious health problems? Yes, DMAA can cause serious health problems, especially when taken in high doses or combined with other stimulants. It has been linked to severe cardiovascular events, including heart attacks and strokes.

  • Is DMAA safe for long-term use? The safety of long-term DMAA use is not well-studied. However, due to its potential for serious side effects and health risks, long-term use is not recommended.

  • Can I take DMAA if I have a pre-existing health condition? If you have a pre-existing health condition, especially a heart condition, you should not take DMAA. Always consult with a healthcare professional before starting any new supplement regimen.

  • Is DMAA safe to take with other supplements or medications? DMAA can interact with other supplements and medications, especially other stimulants. This can increase the risk of serious side effects. Always consult with a healthcare professional before combining DMAA with other supplements or medications.

  • What should I do if I experience side effects from DMAA? If you experience side effects from DMAA, such as rapid heartbeat, chest pain, shortness of breath, or severe headache, seek medical attention immediately.

  • Is DMAA addictive? While DMAA is not typically considered addictive, it can cause dependence and withdrawal symptoms when used regularly.

  • Can DMAA cause a positive drug test? Yes, DMAA can cause a positive result on a drug test for amphetamines.

  • Is DMAA legal? The legal status of DMAA varies by country. In the United States, DMAA is considered a controlled substance and not legal for dietary supplement use.

  • What are the alternatives to DMAA? There are many legal and safe alternatives to DMAA, including caffeine, L-theanine, and B-vitamins. These can provide similar benefits for energy and focus without the risks associated with DMAA.

Bottom Line

While DMAA is often used for its stimulant effects, its safety profile remains a topic of debate.

The lack of comprehensive research on its long-term effects and the potential for serious health risks underscore the need for caution when considering its use.

Always consult with a healthcare professional before starting any new supplement regimen, especially those containing potent stimulants like DMAA.

by Nader Qudimat

Forged by iron and cold steel, I'm Nader, a mid-30s natural bodybuilder. Once a 100lb skinny guy, I've transformed into a 200lb muscular athlete with over 15 years of lifting experience. Today, I leverage my transformation and extensive experience to guide countless individuals on their fitness journeys.

Click here to check out my 12 year transformation: Natural 12 Year Transformation

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