Cycle Support Guide: 4 Best Supplements For Organ Protection

by Nader Qudimat
Updated November 2, 2021

You've realized health is important...

But when you take strong anabolics like prohormones or steroids, your body tends to take a beating from the inside.

A supplement that supports the organs and the body can ensure protection all around.

But what cycle support supplement should you go with?

We've done the research and have found the best on cycle support supplements.

Defend by Huge Nutrition

Defend is a complete formula for organ defense which will optimize healthy functions through different angles.

Containing 120 capsules per bottle, this is one of the most comprehensive on-cycle supplements you can get today.

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Liver & Organ Defender by 5% Nutrition

Liver & Organ defender is a well rounded on cycle protection supplement with lots of ingredients.

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What is a on-cycle support supplement?

When you take harsh anabolics like steroids, prohormones or even SARMs, you risk liver toxicity among other issues as these tend to be harsh on your insides.

See also 1-AndroArimistane and Epiandro

To help protect you against the toxicity of these, it's important to take a cycle support supplement to help protect and support your organs.

Best On Cycle Support Supplements


Defend by Huge Nutrition


Taking anabolics can lead to nasty damage to your organs, but luckily, we have found the best on cycle supplement so far.

Defend is a cycle support supplement with a blend of 7 potent ingredients at clinical doses and they have strong protective effects.

Each bottle contains 30 servings with 120 capsules, allowing for a full month's usage.

The ingredients are the best for the organs, starting with a full gram of milk thistle, which is rare to see in most cycle support supplements.

For example, Advanced Cycle Support by Iron Labs only has 500mg milk thistle, 400mg NAC and 200mg saw palmetto.

Defend spares no expense when it came to formulating it.

Milk thistle is important because it has antioxidant effects on the body, and historically it's used to strengthen liver and gallbladder health. 

Today it's used to potentially enhance and protect liver function.

Luckily, Defend has a standardized 80% of silymarin, which is where the benefits come from.  

NAC is N-Acetyl-Cysteine, an essential amino acid with antioxidant prosperities.

Studies show it can improve kidney and liver health.

Research even shows it can reduce the damage done to organs. 

Peppermint leaf is another ingredient in Defend and it's been shown to aid with digestion, bloating and gas.

It can even relax the digestive system and relieve pain.

This helps with bodybuilders especially because they tend to eat a lot of food which can cause stress.

To aid with prostate health, Huge Nutrition has added Saw Palmetto to help decrease inflammation and improve hair. 

Hair loss is common when you take or have taken anabolics that increase testosterone.

Saw Palmetto is used to reduce the hormone DHT which can cause hair loss. 

It also has testosterone supporting properties to help optimize test production.

Defend still has 3 more ingredients and they are, red clover, TUDCA, and hawthorn berry extract.

Hawthorn berry extract is a strong antioxidant that can help with heart health and keep cholesterol in balance.

Anabolics can have a negative effect on cholesterol and this ingredient alone can help reduce bad cholesterol.

Another useful ingredient in Defend is Red Clover, it's been shown to help with blood pressure.

Research and many studies have found red clover to have a positive effect on blood pressure. 

Tudca is found in the body as a bile salt and it has strong effects on the health particularly the liver but it also has potential for other organs.

Research has found this ingredient can help with liver issues without causing any side effects. 

Defend is clearly a formula that is unmatched by other organ support supplements.

Every other supplement we found had less ingredients, smaller doses and the same prices.

You should use Defend when you're going through an oral cycle that has liver toxicity, like prohormones, steroids and SARMs.

Taking these compounds orally can cause great stress and havoc on organs, which is why an cycle support supplement is essential.

You can also take this as an everyday supplement to help maximize your organ health as the research shows that these ingredients are safe to take and can even undo damage done on the organs.

The best price we found for Defend is 45$, using our coupon code FITFREK.

Defend is a top tier cycle supplement and will protect your organs and keep them functioning optimally.

Use discount code FITFREK.

Most potent organ and liver support formula
Reverses and protects damage done to organs
Fairly priced

Liver and Organ Protection by Rich Piana 5% Nutrition


Liver and Organ Protection lives up to the brand of Rich Piana's 5% Nutrition. 

It's packed with several ingredients from NAC, to milk thistle, hawthorn berry powder, alpha lipoic acid, minerals and more. 

It even has cordyceps, an ingredient that helps with energy and endurance. 

It'll help improve performance and recovery. 

Packed formula for organ support
Contains mushrooms for physical and mental performance
Minerals and basic ingredients to help keep body functioning optimally

Advanced Cycle Support by Iron Mag Labs


Honestly this is one of the smaller formula's we've seen. 

This is something that would've been recommended in 2010, because that's when you can get away with small doses like these. 

You would need to take double servings to make the most out of these ingredients. 

Milk thistle needs to be at a gram, and N-Acetyl-Cysteine is also dosed at less than half of what it should be. 

If you find this on sale, it might be worth getting, like maybe 10-15$. 

Anything more than that, and you're just getting ripped off. 

Contains useful ingredients

Cycle Organ Support by Phase One Nutrition


This formula looks good, and it has everything from organ support to estrogen control.

Androsta-3,5,-Diene-7,17-Dione is known as Arimistane and it's known to help keep estrogen in control. 

Cycle Organ Support looks better than Advanced Cycle Support by Iron Mag Labs.

Use coupon code FITFREK

Organ support
Decreases estrogen
Keeps liver functioning at optimal levels

Cycle Assist by Competitive Edge Labs


Cycle Assist was among the first prohormone support products to appear on the market.

It remains very popular due to its ability to protect the liver, and control blood pressure and lipid levels.

The ingredient profile is pretty impressive, running to ten ingredients.

They include all of the most proven cycle support ingredients in clinically approved dosages.

You won’t find any filler ingredients in this product.

Furthermore every ingredient is standardized extract with the standardization amount clearly shown on the label.

The combination of a competitive price, standardization of all ingredients to improve their bioavailability and a comprehensive formula that's well dosed makes Cycle Assist from competitive Edge Labs an excellent choice.

Standard Ingredients
Well dosed
No filler ingredients
Liver, blood pressure and prostate support

Gear Support Blackstone Labs


Gear Support from Blackstone Labs is designed to protect your organs while you are on-cycle.

It also claims to be able to support ther prostate and help ensure a healthy lipid profile.

It provides a good blend of six well-known ingredients though they are not dosed as highly as in some other popular cycle support product, such as Defend by Huge Nutrition.

Online reviewers are generally positive about their experience using Gear Support, though some feel that it is underdosed and, therefore, not as potent as it could be.

Suppprts liver cleaning, prostate health and lipid profile
Well priced
45-day supply
Some ingredients a little underdosed

Jacked Factory Defend XT


Jacked Factory Defend XT is a simple liver and organ support product that has only three ingredients; milk thistle, Bergavit 40 and Black Pepper Fruit Extract.

Milk thistle is a well established anti-inflammatory, anti-viral and antioxidant seed that supports liver function.

Bergavit 40 is an interesting ingredient that I haven’t seem in any other cycle support products.

It is a patented extract of citrus bergamot fruit that is believed to reduce cholesterol and blood pressure levels.

Bioperine is an antioxidant that can help to prevent the free radical damage that resukts from oxidative stress.

User reviews provide overall favorable reports Defend XT.

It would have been good, though, to have seen a few more proven ingredients in here.

Milk Thistle at a good dosage
Patented Bergavit® 40 extract
Reduces cholesterol and blood pressure
Missing some proven ingreidents

Purus Labs Organ Shield


Purus Labs Organ Shield is a blend of seven plant based antioxidants designed to provide the on-cycle support you need.

The synergistic effect of these compounds will also fight the free radical damage that can result from intense workouts.

Organ Shield includes ingredients that are well attested and the dosages, though a little lower than some popular competitors, are still well within the ballpark for effective organ support.

This product is well priced, being a little lower than most leading competitors.

Purus Labs Organ Shield is an effective on-cycle support product to help support your organs.

It can also be used off-cycle to reduce free radical damage resulting from hard training in the gym.

7 proven plant-based ingredients
On cycle and off-ccyle supprt
Well priced
Some dosages a little low


What's The Best Cycle Support?

The best cycle support is Defend by Huge Nutrition.

It provides seven of the most potent organ and liver support ingredients that are available.

Defend is better dosed than any competing on-cycle support product on the market.

It’s also very well priced.

What Supplements Should I Take On Gear?

When you are on gear, you should take a well dosed cycle support supplement.

It should include such proven ingredients as milk thistle, N-Acetyl-L-Cysteine (NAC), Coenzyme Q10 and Hawthorn Berry Extract.

After an exhaustive review of the market, we have found Defend by Huge Nutrition to be the best supplement to take when you are on gear.

Does Milk Thistle Interact With Gear?

No, milk thistle will not interact with gear.

Milk thistle is an important ingredient to take as part of an on-cycle supplement as it has proven anti-inflammatory, anti-viral and antioxidant and supports liver fuinctioning.

What Organ Support Supplement To Choose?

The best organ support supplement to choose is Defend by Huge Nutrition.

It is the most potent liver and organ support product on the market, reverse and protects damage done to organs and is well priced.

What Should I Do After A Cycle?

After a cycle, you should run a post cycle therapy (PCT).

This will help to restore your body’s natural production of testosterone, which may completely shut down over the course of a 12-week cycle.

You can find out more about what to do after your cycle here.

Does Cycle Support Guarantee Protection Against Steroids And / Or Prohormones?

No, cycle support does not guarantee protection against steroids and / or prohormones.

Some steroid cycles run a higher risk of organ damage than others.

The dosage of your cycle will also play its part.

Cycle support, though, will help to minimize the damage.

What Are On Cycle Support Supplements?

When you take harsh anabolics like steroids, prohormones or even SARMs, you risk liver toxicity among other issues as these tend to be harsh on your insides.

To help protect you against the toxicity of these, it's important to take a cycle support supplement to help protect and support your organs.

On-Cycle Support VS PCT

It's important to remember that PCT is different than on-cycle support.

PCT is the care after the cycle is completed to help jump start the testosterone production and help control estrogen.

Using a PCT will help keep estrogen in check while jump starting the testosterone production.

This is why you can stack a testosterone booster with a PCT or use something like Rebirth which already has a testosterone boosting blend in it.

Huge Nutrition's muscle building stacks will help you keep your the gains you've made after your cycle, which can be stacked with their pre workout.

How long or how much PCT and on-cycle support will depend on the harshness of your anabolic cycle.

Why Use Cycle Support?

When you take anabolics like steroids, prohormones or SARMs, your body's normal hormone production changes.

Some of these are negative as there's side effects to every drastic change you make to your body.

Some of these side effects include:

  • Hair loss
  • Mood changes
  • Libido changes
  • Pain in joints
  • Lower back pumps (from high blood pressure)
  • Prostate changes
  • Acne
  • And more

These side effects will depend on the individual and their genetics.

If you have a history of a medical issue, some anabolics can increase the risk like higher blood pressure or heart problems.

On cycle supplements will help manage these issues and make them less severe.

Check out these joint support supplements.

What Are The Best Cycle Support Ingredients?

The six best cycle support ingredients that are backed by science are:

  • N-Acetyl-L-Cysteine (NAC)

N-Acetyl-L-Cysteine or NAC is known to help with glutathione production, a potent antioxidant. It helps optimize liver function and it can even improve symptoms found in alcoholics.

  • Milk Thistle

Milk thistle, or Silymarin, is traditionally used in ancient medicine to fight liver conditions. It functions as a antioxidant that can fight free radicals. research has seen milk thistle to improve liver function.


TUDCA, known as Tauroursodeoxycholic acid, occurs naturally in the body as a bile salt.

It reduces liver enzymes as research has found and can help enhance liver health. 

  • Coenzyme Q10

COQ10 is a strong antioxidant that can protect the liver from damage.

Research has found this ingredient to improve systemic inflammation and biochemical variables.

  • Hawthorn Berry Extract
  • Red Clover

What Are The Best On Cycle Support Supplements?

What Supplement Has All Of These Ingredients?

Defend by Huge Nutrition includes all of these ingredients in the ideal dosages.

The best price we found for Defend is 45$, using our coupon code FITFREK.

by Nader Qudimat

Forged by the iron and cold steel, Nader takes his knowledge and hulks it up into this site.

Having to be stuck as a 110lb skinny guy in the early days, he has had no choice but to keep improving himself until he cannot.

Click here to check out his 12 year transformation: Natural 12 Year Transformation

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