Cycle Support Guide: 4 Best Supplements For Organ Protection

by Nader Qudimat
Updated November 2, 2021

You've realized health is important...

But when you take strong anabolics like prohormones or steroids, your body tends to take a beating from the inside.

A supplement that supports the organs and the body can ensure protection all around.

But what cycle support supplement should you go with?

We've done the research and have found the best on cycle support supplements.

Defend by Huge Nutrition

Defend is a monster of a formula with lots of ingredients that'll optimize healthy functions through different angles.

Use discount code FITFREK

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Liver & Organ Defender by 5% Nutrition

Liver & Organ defender is a well rounded on cycle protection supplement with lots of ingredients.

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We earn a commission if you make a purchase, at no additional cost to you.

What is a on-cycle support supplement?

When you take harsh anabolics like steroids, prohormones or even SARMs, you risk liver toxicity among other issues as these tend to be harsh on your insides.

See also 1-AndroArimistane and Epiandro

To help protect you against the toxicity of these, it's important to take a cycle support supplement to help protect and support your organs.

Best On Cycle Support Supplements


Defend by Huge Nutrition

Most potent organ and liver support formula
Reverses and protects damage done to organs
Fairly priced

Taking anabolics can lead to nasty damage to your organs, but luckily, we have found the best on cycle supplement so far.

Defend is a cycle support supplement with a blend of 7 potent ingredients at clinical doses and they have strong protective effects.

Each bottle contains 30 servings with 120 capsules, allowing for a full month's usage.

The ingredients are the best for the organs, starting with a full gram of milk thistle, which is rare to see in most cycle support supplements.

For example, Advanced Cycle Support by Iron Labs only has 500mg milk thistle, 400mg NAC and 200mg saw palmetto.

Defend spares no expense when it came to formulating it.

Milk thistle is important because it has antioxidant effects on the body, and historically it's used to strengthen liver and gallbladder health. 

Today it's used to potentially enhance and protect liver function.

Luckily, Defend has a standardized 80% of silymarin, which is where the benefits come from.  

NAC is N-Acetyl-Cysteine, an essential amino acid with antioxidant prosperities.

Studies show it can improve kidney and liver health.

Research even shows it can reduce the damage done to organs. 

Peppermint leaf is another ingredient in Defend and it's been shown to aid with digestion, bloating and gas.

It can even relax the digestive system and relieve pain.

This helps with bodybuilders especially because they tend to eat a lot of food which can cause stress.

To aid with prostate health, Huge Nutrition has added Saw Palmetto to help decrease inflammation and improve hair. 

Hair loss is common when you take or have taken anabolics that increase testosterone.

Saw Palmetto is used to reduce the hormone DHT which can cause hair loss. 

It also has testosterone supporting properties to help optimize test production.

Defend still has 3 more ingredients and they are, red clover, TUDCA, and hawthorn berry extract.

Hawthorn berry extract is a strong antioxidant that can help with heart health and keep cholesterol in balance.

Anabolics can have a negative effect on cholesterol and this ingredient alone can help reduce bad cholesterol.

Another useful ingredient in Defend is Red Clover, it's been shown to help with blood pressure.

Research and many studies have found red clover to have a positive effect on blood pressure. 

Tudca is found in the body as a bile salt and it has strong effects on the health particularly the liver but it also has potential for other organs.

Research has found this ingredient can help with liver issues without causing any side effects. 

Defend is clearly a formula that is unmatched by other organ support supplements.

Every other supplement we found had less ingredients, smaller doses and the same prices.

You should use Defend when you're going through an oral cycle that has liver toxicity, like prohormones, steroids and SARMs.

Taking these compounds orally can cause great stress and havoc on organs, which is why an cycle support supplement is essential.

You can also take this as an everyday supplement to help maximize your organ health as the research shows that these ingredients are safe to take and can even undo damage done on the organs.

The best price we found for Defend is 45$, using our coupon code FITFREK.

Defend is a top tier cycle supplement and will protect your organs and keep them functioning optimally.

Use discount code FITFREK.


Liver and Organ Protection by Rich Piana 5% Nutrition

Packed formula for organ support
Contains mushrooms for physical and mental performance
Minerals and basic ingredients to help keep body functioning optimally

Liver and Organ Protection lives up to the brand of Rich Piana's 5% Nutrition. 

It's packed with several ingredients from NAC, to milk thistle, hawthorn berry powder, alpha lipoic acid, minerals and more. 

It even has cordyceps, an ingredient that helps with energy and endurance. 

It'll help improve performance and recovery. 


Advanced Cycle Support by Iron Mag Labs

Contains useful ingredients

Honestly this is one of the smaller formula's we've seen. 

This is something that would've been recommended in 2010, because that's when you can get away with small doses like these. 

You would need to take double servings to make the most out of these ingredients. 

Milk thistle needs to be at a gram, and N-Acetyl-Cysteine is also dosed at less than half of what it should be. 

If you find this on sale, it might be worth getting, like maybe 10-15$. 

Anything more than that, and you're just getting ripped off. 


Cycle Organ Support by Phase One Nutrition

Organ support
Decreases estrogen
Keeps liver functioning at optimal levels

This formula looks good, and it has everything from organ support to estrogen control.

Androsta-3,5,-Diene-7,17-Dione is known as Arimistane and it's known to help keep estrogen in control. 

Cycle Organ Support looks better than Advanced Cycle Support by Iron Mag Labs.

Use coupon code FITFREK


What Are On Cycle Support Supplements?

When you take harsh anabolics like steroids, prohormones or even SARMs, you risk liver toxicity among other issues as these tend to be harsh on your insides.

To help protect you against the toxicity of these, it's important to take a cycle support supplement to help protect and support your organs.

On-Cycle Support VS PCT

It's important to remember that PCT is different than on-cycle support.

PCT is the care after the cycle is completed to help jump start the testosterone production and help control estrogen.

Using a PCT will help keep estrogen in check while jump starting the testosterone production.

This is why you can stack a testosterone booster with a PCT or use something like Rebirth which already has a testosterone boosting blend in it.

Huge Nutrition's muscle building stacks will help you keep your the gains you've made after your cycle, which can be stacked with their pre workout.

How long or how much PCT and on-cycle support will depend on the harshness of your anabolic cycle.

Why Use Cycle Support?

When you take anabolics like steroids, prohormones or SARMs, your body's normal hormone production changes.

Some of these are negative as there's side effects to every drastic change you make to your body.

Some of these side effects include:

  • Hair loss
  • Mood changes
  • Libido changes
  • Pain in joints
  • Lower back pumps (from high blood pressure)
  • Prostate changes
  • Acne
  • And more

These side effects will depend on the individual and their genetics.

If you have a history of a medical issue, some anabolics can increase the risk like higher blood pressure or heart problems.

On cycle supplements will help manage these issues and make them less severe.

Check out these joint support supplements.

Best On-Cycle Support Ingredients

Here are the most important ingredients for the liver:

  • N-Acetyl-L-Cysteine (NAC)

N-Acetyl-L-Cysteine or NAC is known to help with glutathione production, a potent antioxidant. It helps optimize liver function and it can even improve symptoms found in alcoholics.

  • Milk Thistle

Milk thistle, or Silymarin, is traditionally used in ancient medicine to fight liver conditions. It functions as a antioxidant that can fight free radicals. research has seen milk thistle to improve liver function.


TUDCA, known as Tauroursodeoxycholic acid, occurs naturally in the body as a bile salt.

It reduces liver enzymes as research has found and can help enhance liver health. 

  • Coenzyme Q10

COQ10 is a strong antioxidant that can protect the liver from damage.

Research has found this ingredient to improve systemic inflammation and biochemical variables.

by Nader Qudimat

Forged by the iron and cold steel, Nader takes his knowledge and hulks it up into this site.

Having to be stuck as a 110lb skinny guy in the early days, he has had no choice but to keep improving himself until he cannot.

Click here to check out his 12 year transformation: Natural 12 Year Transformation

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