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Cycle Support Guide: 4 Best Supplements For Organ Protection [Updated 2024]

by Nader Qudimat
Updated December 21, 2023

So, you've come to understand the importance of health...

Especially when you're dealing with potent anabolics like prohormones or steroids, your body can often feel like it's under siege from within.

That's where a supplement that provides comprehensive organ and body support comes into play. It's like your personal bodyguard, ensuring all-round protection.

But the question is, which cycle support supplement should you choose?

Don't worry, we've got your back. We've done the legwork and rounded up the best on-cycle support supplements out there.

RECOMMENDED
Defend by Huge Nutrition

Defend is a complete formula for organ defense which will optimize healthy functions through different angles.

Containing 360 capsules per bottle, this is one of the most comprehensive on-cycle supplements you can get today.

Use discount code FITFREK

Highlights:
  • Most potent organ and liver support formula
  • Reverses and protects damage done to organs
  • Fairly priced
Ingredients: 1000mg Milk Thistle Extract, 600mg N-Acetyl-Cysteine, 500mg Peppermint Leaf Powder, 250mg TUDCA, 200mg Red Clover, 150mg Hawthorn Berry Extract, 250mg Saw Palmetto Extract
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VALUE PICK
Liver & Organ Defender by 5% Nutrition

Liver & Organ defender is a well rounded on cycle protection supplement with lots of ingredients.

Use discount code FITFREK

CHECK IT OUT
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But first, let's get clear on what an on-cycle support supplement is.

When you're taking heavy-duty anabolics like steroids, prohormones, or even SARMs, you're playing with fire.

These substances can be harsh on your insides, risking liver toxicity among other issues.

Take a look at 1-Andro, Arimistane, and Epiandro for instance.

That's why it's crucial to have a cycle support supplement in your corner. It's there to protect and support your organs against the toxicity of these substances.

It's like having a personal health coach, making sure you're staying safe while you're pushing your limits.

Best On Cycle Support Supplements

BEST CYCLE SUPPORT

Defend by Huge Nutrition

RECOMMENDED
Defend by Huge Nutrition

Defend is a complete formula for organ defense which will optimize healthy functions through different angles.

Containing 360 capsules per bottle, this is one of the most comprehensive on-cycle supplements you can get today.

Use discount code FITFREK

Highlights:
  • Most potent organ and liver support formula
  • Reverses and protects damage done to organs
  • Fairly priced
Ingredients: 1000mg Milk Thistle Extract, 600mg N-Acetyl-Cysteine, 500mg Peppermint Leaf Powder, 250mg TUDCA, 200mg Red Clover, 150mg Hawthorn Berry Extract, 250mg Saw Palmetto Extract
CHECK IT OUT
FitFrek earns a commission if you click this link and make a purchase, at no additional cost to you.

Taking anabolics can lead to nasty damage to your organs, but luckily, we have found the best on cycle supplement so far.

Defend is a cycle support supplement with a blend of 7 potent ingredients at clinical doses and they have strong protective effects.

Each bottle contains 30 servings with 120 capsules, allowing for a full month's usage.

The ingredients are the best for the organs, starting with a full gram of milk thistle, which is rare to see in most cycle support supplements.

For example, Advanced Cycle Support by Iron Labs only has 500mg milk thistle, 400mg NAC and 200mg saw palmetto.

Defend spares no expense when it came to formulating it.

Milk thistle is important because it has antioxidant effects on the body, and historically it's used to strengthen liver and gallbladder health. 

Today it's used to potentially enhance and protect liver function.

Luckily, Defend has a standardized 80% of silymarin, which is where the benefits come from.  

NAC is N-Acetyl-Cysteine, an essential amino acid with antioxidant prosperities.

Studies show it can improve kidney and liver health.

Research even shows it can reduce the damage done to organs. 

Peppermint leaf is another ingredient in Defend and it's been shown to aid with digestion, bloating and gas.

It can even relax the digestive system and relieve pain.

This helps with bodybuilders especially because they tend to eat a lot of food which can cause stress.

To aid with prostate health, Huge Nutrition has added Saw Palmetto to help decrease inflammation and improve hair. 

Hair loss is common when you take or have taken anabolics that increase testosterone.

Saw Palmetto is used to reduce the hormone DHT which can cause hair loss. 

It also has testosterone supporting properties to help optimize test production.

Defend still has 3 more ingredients and they are, red clover, TUDCA, and hawthorn berry extract.

Hawthorn berry extract is a strong antioxidant that can help with heart health and keep cholesterol in balance.

Anabolics can have a negative effect on cholesterol and this ingredient alone can help reduce bad cholesterol.

Another useful ingredient in Defend is Red Clover, it's been shown to help with blood pressure.

Research and many studies have found red clover to have a positive effect on blood pressure. 

Tudca is found in the body as a bile salt and it has strong effects on the health particularly the liver but it also has potential for other organs.

Research has found this ingredient can help with liver issues without causing any side effects. 

Defend is clearly a formula that is unmatched by other organ support supplements.

Every other supplement we found had less ingredients, smaller doses and the same prices.

You should use Defend when you're going through an oral cycle that has liver toxicity, like prohormones, steroids and SARMs.

Taking these compounds orally can cause great stress and havoc on organs, which is why an cycle support supplement is essential.

You can also take this as an everyday supplement to help maximize your organ health as the research shows that these ingredients are safe to take and can even undo damage done on the organs.

The best price we found for Defend is 45$, using our coupon code FITFREK.

Defend is a top tier cycle supplement and will protect your organs and keep them functioning optimally.

Use discount code FITFREK.

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WELL ROUNDED

Liver and Organ Protection by Rich Piana 5% Nutrition

$59.99
on ...com
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INGREDIENTS:

Liver and Organ Protection lives up to the brand of Rich Piana's 5% Nutrition. 

It's packed with several ingredients from NAC, to milk thistle, hawthorn berry powder, alpha lipoic acid, minerals and more. 

It even has cordyceps, an ingredient that helps with energy and endurance. 

It'll help improve performance and recovery. 

Packed formula for organ support
Contains mushrooms for physical and mental performance
Minerals and basic ingredients to help keep body functioning optimally
None
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ESTROGEN CONTROL

Gear Support Blackstone Labs

$59.99
on ...com
CHECK IT OUT 
INGREDIENTS:

Gear Support from Blackstone Labs is designed to protect your organs while you are on-cycle.

It also claims to be able to support ther prostate and help ensure a healthy lipid profile.

It provides a good blend of six well-known ingredients though they are not dosed as highly as in some other popular cycle support product, such as Defend by Huge Nutrition.

Online reviewers are generally positive about their experience using Gear Support, though some feel that it is underdosed and, therefore, not as potent as it could be.

Suppprts liver cleaning, prostate health and lipid profile
Well priced
45-day supply
Some ingredients a little underdosed
CHECK IT OUT
ESTROGEN CONTROL

Jacked Factory Defend XT

$59.99
on ...com
CHECK IT OUT 
INGREDIENTS:

Jacked Factory Defend XT is a simple liver and organ support product that has only three ingredients; milk thistle, Bergavit 40 and Black Pepper Fruit Extract.

Milk thistle is a well established anti-inflammatory, anti-viral and antioxidant seed that supports liver function.

Bergavit 40 is an interesting ingredient that I haven’t seem in any other cycle support products.

It is a patented extract of citrus bergamot fruit that is believed to reduce cholesterol and blood pressure levels.

Bioperine is an antioxidant that can help to prevent the free radical damage that resukts from oxidative stress.

User reviews provide overall favorable reports Defend XT.

It would have been good, though, to have seen a few more proven ingredients in here.

Milk Thistle at a good dosage
Patented Bergavit® 40 extract
Reduces cholesterol and blood pressure
Missing some proven ingreidents
CHECK IT OUT
ESTROGEN CONTROL

Purus Labs Organ Shield

$59.99
on ...com
CHECK IT OUT 
INGREDIENTS:

Purus Labs Organ Shield is a blend of seven plant based antioxidants designed to provide the on-cycle support you need.

The synergistic effect of these compounds will also fight the free radical damage that can result from intense workouts.

Organ Shield includes ingredients that are well attested and the dosages, though a little lower than some popular competitors, are still well within the ballpark for effective organ support.

This product is well priced, being a little lower than most leading competitors.

Purus Labs Organ Shield is an effective on-cycle support product to help support your organs.

It can also be used off-cycle to reduce free radical damage resulting from hard training in the gym.

7 proven plant-based ingredients
On cycle and off-ccyle supprt
Well priced
Some dosages a little low
CHECK IT OUT

Organ Supplements for On-Cycle Support

Organ support supplements are gaining popularity and for good reason.

They're designed to provide your body with the nutrients it needs to support the health and function of your vital organs.

Your organs are the workhorses of your body.

They perform vital functions that keep you alive and well.

From your heart pumping blood to your liver detoxifying harmful substances, your organs are always hard at work.

Organ support supplements are specially formulated to provide targeted support to specific organs.

They contain a blend of vitamins, minerals, herbs, and other nutrients that are known to support organ health and function.

Top Organ Support Supplements

These supplements are shown to be the most effective when it comes to organ support...

Liver Support Supplements

The liver is your body's natural detoxifier. It filters out toxins from your blood and helps metabolize drugs and alcohol.

Liver support supplements often contain ingredients like milk thistle and artichoke leaf, which are known to support liver health [1].

Kidney Support Supplements

Your kidneys filter waste products out of your blood and regulate your body's fluid and electrolyte balance.

Kidney support supplements often contain herbs like dandelion root, which is known to support kidney health [2].

Heart Support Supplements

The heart is arguably the most important organ in your body.

It pumps blood throughout your body, supplying your organs with the oxygen and nutrients they need to function.

Heart support supplements often contain omega-3 fatty acids and coenzyme Q10, which are known to support heart health [3].

Key Ingredients in Organ Support Supplements

Milk Thistle

Milk thistle is a popular ingredient in liver support supplements. It's been used for over 2,000 years to treat liver disorders.

The active substance in milk thistle is silymarin, which is made up of several natural plant chemicals.

Lab studies suggest that silymarin helps regenerate liver tissue, reduce inflammation, and protect liver cells from damage[4].

Artichoke Leaf

Artichoke leaf has antioxidant properties and may protect the liver.

Research done in animals shows it may help liver cells regenerate.

In studies of people with nonalcoholic fatty liver disease, artichoke leaf reduced markers of liver damage compared with placebo[5].

Dandelion Root

Though dandelion has been used to treat liver ailments, evidence of its benefits is scarce.

Much more research is needed to determine whether it's safe and effective for this purpose[6].

How Organ Support Supplements Work

Organ support supplements work by providing your organs with the nutrients they need to function optimally.

They can help support organ health, improve organ function, and protect your organs from damage by acting as antioxidants, reducing inflammation, and promoting the regeneration of organ tissue.

Benefits of Organ Support Supplements

Organ support supplements offer a range of potential benefits. They can help support the health and function of your organs, improve your body's natural detoxification processes, and provide your body with essential nutrients. They may also help protect your organs from damage caused by toxins, alcohol, and other harmful substances.

Choosing the Right Organ Support Supplement

Choosing the right organ support supplement depends on your individual health needs.

It's important to talk to your doctor or a qualified health professional before starting any new supplement regimen.

They can help you choose a supplement that's right for you and guide you on the appropriate dosage.

Safety and Side Effects of Organ Support Supplements

While organ support supplements are generally safe for most people, they can cause side effects in some cases.

These can include digestive upset, allergic reactions, and interactions with medications.

It's always a good idea to talk to your doctor before starting any new supplement regimen.

The Role of Diet and Lifestyle in Organ Health

While supplements can provide targeted support to your organs, it's important to remember that your diet and lifestyle play a crucial role in organ health.

Eating a balanced diet, getting regular exercise, avoiding toxins, and managing stress are all important for maintaining the health and function of your organs.

Expert Opinions on Organ Support Supplements

Many health professionals recommend organ support supplements as part of a comprehensive approach to health and wellness.

However, it's important to remember that supplements should not be used as a substitute for a healthy diet and lifestyle.

Case Studies and Research on Organ Support Supplements

There is a growing body of research on the potential benefits of organ support supplements.

However, more research is needed to fully understand their effects and to determine the optimal dosages for different individuals.

Top Organ Support Supplements

Organ support supplements are gaining popularity and for good reason.

They're designed to provide your body with the nutrients it needs to support the health and function of your vital organs.

Your organs are the workhorses of your body.

They perform vital functions that keep you alive and well.

From your heart pumping blood to your liver detoxifying harmful substances, your organs are always hard at work.

Organ support supplements are specially formulated to provide targeted support to specific organs.

They contain a blend of vitamins, minerals, herbs, and other nutrients that are known to support organ health and function.

These supplements are shown to be the most effective when it comes to organ support...

Liver Support Supplements

The liver is your body's natural detoxifier. It filters out toxins from your blood and helps metabolize drugs and alcohol.

Liver support supplements often contain ingredients like milk thistle and artichoke leaf, which are known to support liver health [1].

Kidney Support Supplements

Your kidneys filter waste products out of your blood and regulate your body's fluid and electrolyte balance.

Kidney support supplements often contain herbs like dandelion root, which is known to support kidney health [7].

Heart Support Supplements

The heart is arguably the most important organ in your body.

It pumps blood throughout your body, supplying your organs with the oxygen and nutrients they need to function.

Heart support supplements often contain omega-3 fatty acids and coenzyme Q10, which are known to support heart health [8].

Key Ingredients in Organ Support Supplements

Milk Thistle

Milk thistle is a popular ingredient in liver support supplements. It's been used for over 2,000 years to treat liver disorders.

The active substance in milk thistle is silymarin, which is made up of several natural plant chemicals.

Lab studies suggest that silymarin helps regenerate liver tissue, reduce inflammation, and protect liver cells from damage[9].

Artichoke Leaf

Artichoke leaf has antioxidant properties and may protect the liver.

Research done in animals shows it may help liver cells regenerate.

In studies of people with nonalcoholic fatty liver disease, artichoke leaf reduced markers of liver damage compared with placebo[5].

Dandelion Root

Though dandelion has been used to treat liver ailments, evidence of its benefits is scarce.

Much more research is needed to determine whether it's safe and effective for this purpose[10].

How Organ Support Supplements Work

Organ support supplements work by providing your organs with the nutrients they need to function optimally.

They can help support organ health, improve organ function, and protect your organs from damage by acting as antioxidants, reducing inflammation, and promoting the regeneration of organ tissue.

Benefits of Organ Support Supplements

Organ support supplements offer a range of potential benefits.

They can help support the health and function of your organs, improve your body's natural detoxification processes, and provide your body with essential nutrients.

They may also help protect your organs from damage caused by toxins, alcohol, and other harmful substances.

Choosing the Right Organ Support Supplement

Choosing the right organ support supplement depends on your individual health needs.

It's important to talk to your doctor or a qualified health professional before starting any new supplement regimen.

They can help you choose a supplement that's right for you and guide you on the appropriate dosage.

Safety and Side Effects of Organ Support Supplements

While organ support supplements are generally safe for most people, they can cause side effects in some cases.

These can include digestive upset, allergic reactions, and interactions with medications.

It's always a good idea to talk to your doctor before starting any new supplement regimen.

The Role of Diet and Lifestyle in Organ Health

While supplements can provide targeted support to your organs, it's important to remember that your diet and lifestyle play a crucial role in organ health.

Eating a balanced diet, getting regular exercise, avoiding toxins, and managing stress are all important for maintaining the health and function of your organs.

Expert Opinions on Organ Support Supplements

Many health professionals recommend organ support supplements as part of a comprehensive approach to health and wellness.

However, it's important to remember that supplements should not be used as a substitute for a healthy diet and lifestyle.

Many health professionals recommend organ support supplements as part of a comprehensive approach to health and wellness.

However, it's important to remember that supplements should not be used as a substitute for a healthy diet and lifestyle.

According to Healthline, while certain ingredients in organ support supplements, such as milk thistle and artichoke leaf, have been found to have potential benefits, these were mainly observed in people with liver disease [11].

Whether these supplements can improve liver function in otherwise healthy people has yet to be proven.

Furthermore, the evidence supporting the benefits of other commonly used ingredients, such as dandelion root, is scarce [12]. More research is needed to determine whether it’s safe and effective for liver health.

Experts also caution that every drug you take has to be broken down and removed by your liver. Chronic use or misuse of drugs like steroids and inhalants can permanently damage this organ.

Therefore, it's crucial to use caution when taking any supplements, especially if you're also taking other medications.

In conclusion, while organ support supplements can provide targeted support to your organs, they should be used as part of a comprehensive approach to health and wellness that includes a healthy diet, regular exercise, and a balanced lifestyle.

Always consult with healthcare professionals when making decisions about diet and health.

Case Studies and Research on Organ Support Supplements

There is a growing body of research on the potential benefits of organ support supplements.

However, more research is needed to fully understand their effects and to determine the optimal dosages for different individuals.

FAQ

What Are Organ Supplement Supplements?

Organ support supplements are specially formulated products that contain a blend of vitamins, minerals, herbs, and other nutrients.

They are designed to provide targeted support to specific organs in the body, such as the liver, kidneys, or heart, and help maintain their optimal function and health.

How do organ support supplements work?

Organ support supplements work by providing your organs with the nutrients they need to function optimally.

They can help support organ health, improve organ function, and protect your organs from damage.

They do this by acting as antioxidants, reducing inflammation, and promoting the regeneration of organ tissue.

What are the potential benefits of organ support supplements?

Organ support supplements can offer a range of potential benefits.

They can help support the health and function of your organs, improve your body's natural detoxification processes, and provide your body with essential nutrients.

They may also help protect your organs from damage caused by toxins, alcohol, and other harmful substances.

Are there any side effects of organ support supplements?

While organ support supplements are generally safe for most people, they can cause side effects in some cases.

These can include digestive upset, allergic reactions, and interactions with medications.

It's always a good idea to talk to your doctor before starting any new supplement regimen.

How do I choose the right organ support supplement for me?

Choosing the right organ support supplement depends on your individual health needs.

It's important to talk to your doctor or a qualified health professional before starting any new supplement regimen.

They can help you choose a supplement that's right for you and guide you on the appropriate dosage.

What's The Best Cycle Support?

The best cycle support is Defend by Huge Nutrition.

It provides seven of the most potent organ and liver support ingredients that are available.

Defend is better dosed than any competing on-cycle support product on the market.

It’s also very well priced.

What Supplements Should I Take On Gear?

When you are on gear, you should take a well dosed cycle support supplement.

It should include such proven ingredients as milk thistle, N-Acetyl-L-Cysteine (NAC), Coenzyme Q10 and Hawthorn Berry Extract.

After an exhaustive review of the market, we have found Defend by Huge Nutrition to be the best supplement to take when you are on gear.

Does Milk Thistle Interact With Gear?

No, milk thistle will not interact with gear.

Milk thistle is an important ingredient to take as part of an on-cycle supplement as it has proven anti-inflammatory, anti-viral and antioxidant and supports liver fuinctioning.

What Organ Support Supplement To Choose?

The best organ support supplement to choose is Defend by Huge Nutrition.

It is the most potent liver and organ support product on the market, reverse and protects damage done to organs and is well priced.

What Should I Do After A Cycle?

After a cycle, you should run a post cycle therapy (PCT).

This will help to restore your body’s natural production of testosterone, which may completely shut down over the course of a 12-week cycle.

You can find out more about what to do after your cycle here.

Does Cycle Support Guarantee Protection Against Steroids And / Or Prohormones?

No, cycle support does not guarantee protection against steroids and / or prohormones.

Some steroid cycles run a higher risk of organ damage than others.

The dosage of your cycle will also play its part.

Cycle support, though, will help to minimize the damage.

What Are On Cycle Support Supplements?

When you take harsh anabolics like steroids, prohormones or even SARMs, you risk liver toxicity among other issues as these tend to be harsh on your insides.

To help protect you against the toxicity of these, it's important to take a cycle support supplement to help protect and support your organs.

On-Cycle Support VS PCT

It's important to remember that PCT is different than on-cycle support.

PCT is the care after the cycle is completed to help jump start the testosterone production and help control estrogen.

Using a PCT will help keep estrogen in check while jump starting the testosterone production.

This is why you can stack a testosterone booster with a PCT or use something like Rebirth which already has a testosterone boosting blend in it.

Huge Nutrition's muscle building stacks will help you keep your the gains you've made after your cycle, which can be stacked with their pre workout.

How long or how much PCT and on-cycle support will depend on the harshness of your anabolic cycle.

Why Use Cycle Support?

When you take anabolics like steroids, prohormones or SARMs, your body's normal hormone production changes.

Some of these are negative as there's side effects to every drastic change you make to your body.

Some of these side effects include:

  • Hair loss
  • Mood changes
  • Libido changes
  • Pain in joints
  • Lower back pumps (from high blood pressure)
  • Prostate changes
  • Acne
  • And more

These side effects will depend on the individual and their genetics.

If you have a history of a medical issue, some anabolics can increase the risk like higher blood pressure or heart problems.

On cycle supplements will help manage these issues and make them less severe.

Check out these joint support supplements.

What Are The Best Cycle Support Ingredients?

The six best cycle support ingredients that are backed by science are:

  • N-Acetyl-L-Cysteine (NAC)

N-Acetyl-L-Cysteine or NAC is known to help with glutathione production, a potent antioxidant. It helps optimize liver function and it can even improve symptoms found in alcoholics.

  • Milk Thistle

Milk thistle, or Silymarin, is traditionally used in ancient medicine to fight liver conditions. It functions as a antioxidant that can fight free radicals. research has seen milk thistle to improve liver function.

  • TUDCA

TUDCA, known as Tauroursodeoxycholic acid, occurs naturally in the body as a bile salt.

It reduces liver enzymes as research has found and can help enhance liver health. 

  • Coenzyme Q10

COQ10 is a strong antioxidant that can protect the liver from damage.

Research has found this ingredient to improve systemic inflammation and biochemical variables.

  • Hawthorn Berry Extract
  • Red Clover

Defend by Huge Nutrition includes all of these ingredients in the ideal dosages.

The best price we found for Defend is 45$, using our coupon code FITFREK.

What Are The Best On Cycle Support Supplements?

The Bottom Line for On-Cycle Support

Alright, let's wrap this up.

Organ support supplements are a big deal in the health and wellness space.

They're packed with nutrients that are specifically designed to give your vital organs a boost.

But remember, they're not a magic pill.

They're meant to complement a healthy diet and lifestyle, not replace it.

Choosing the right supplement is a personal journey.

It depends on your individual health needs and goals.

And while these supplements are generally safe, it's always a smart move to chat with your healthcare provider before starting any new supplement regimen.

The research on organ support supplements is promising, but it's still ongoing. Some ingredients have shown some pretty impressive results, but more studies are needed to confirm these benefits and figure out the best dosages.

So, are organ support supplements worth it?

They can be a valuable addition to a health-conscious lifestyle. But like anything, they should be used responsibly.

Pair them with a balanced diet, regular exercise, and always listen to the advice of your healthcare professional.

And there you have it: a deep dive into the world of organ support supplements.

Whether you're already a supplement pro or just starting your journey, I hope this guide has given you some valuable insights.

And now I'd love to hear from you:

Have you tried any organ support supplements? What was your experience? Let me know in the comments below.

by Nader Qudimat

Forged by iron and cold steel, I'm Nader, a mid-30s natural bodybuilder. Once a 100lb skinny guy, I've transformed into a 200lb muscular athlete with over 15 years of lifting experience. Today, I leverage my transformation and extensive experience to guide countless individuals on their fitness journeys.

Click here to check out my 12 year transformation: Natural 12 Year Transformation

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