Top 3 Muscle Building Supplement Stacks That Actually Work [Updated 2023]

by Nader Qudimat
Updated January 19, 2023

Sometimes one supplement isn’t enough.

You’re looking for a complete, all in one muscle building stack that works.

When it’s a stack, it is specifically designed to maximize results, muscle gains and efficiency. 

Advanced Anabolic Stack by Huge Supplements

Ecdysterone and Sapogenix is a potent combo that'll help increase muscle size and strength through plant-based steroids.

  • One of the strongest plant-based anabolic stacks
  • Uses potent natural anabolics
  • Increases strength and muscle size
Ingredients: Dioscorea Makino Extract, Ecdysterone Hydroxypropyl B-Cyclodextrin Complex
Discount code: FITFREK
FitFrek earns a commission if you click this link and make a purchase, at no additional cost to you.

Taking single supplements can still work well.

But when it’s a full stack, everything is optimized from every possible angle. 

How do you know what to go with ?

You have two options:

You can make your own stack. 

Or you can get the best bang for your buck and get a pre made one. 

We’ve done the research and have found the best stack for muscle gains. 

We’ll start with the most effective stack…

Muscle Building Stacks That Actually Work in 2023


Muscle Building Essentials

Bulk Muscle Building Essentials Stack by Transparent Labs

Transparent Labs Muscle Building Stack is one of the most complete stacks we've seen. It does come with a high price but you can use our discount code FITFREK

  • Complete stack for muscle building
  • Comes with pre-workout
  • Enhances recovery
Supplements: Growth, 100% Protein Isolate, Bulk, Creatine HMB
Discount code: FITFREK
FitFrek earns a commission if you click this link and make a purchase, at no additional cost to you.

When it comes to naturally sweetened supplements, this company does it the best. 

Transparent Labs doesn't use any artificial sweeteners or preservatives but they still create some of the most effective supplements we've seen. 

This stack includes:

  • Bulk
  • Growth
  • 100% Grass-Fed Protein Isolate
  • Creatine HMB 

All of these supplements will enhance recovery and you'll be able to hit the gym with 100% effort quicker. 

It also comes with Bulk, a pre-workout that has just enough caffeine to power you through your workouts but without being overpowered with stimulants.


Supplements In Huge Nutrition's Stacks




Enhance is Huge Nutrition’s testosterone booster. 

Huge Nutrition has a few anabolic supplements, but this is designed to maximize testosterone production.

Starting off with 4000iu vitamin D3, this is a vital ingredient to have for testosterone production. 

Most men are deficient with this vitamin because of not getting enough sunlight. 

Zinc is next and this is another vitamin that plays a role in testosterone production.

Even athletes struggle with their zinc intake and this is important to have for proper immune function as it can act as an antibacterial agent.

It’s an important mineral to have for protein synthesis and consuming it in a supplement ensures you get enough of it. 

SelenoExcell is a patented ingredient of selenium and since it’s a trace mineral, the body only requires a little amount to get the most out of it. 

Being deficient in selenium puts your health at risk for chronic conditions like infections, cancer and heart related diseases. 

The main reason why it’s here is because it has potent antioxidant properties.

Together with zinc, it will help keep your immune system strong.

In addition to vitamin D3 and selenium is boron citrate, another important mineral that plays a role in bone health, wound healing, and has properties for being anti-inflammatory as well as being able to enhance cognition, estrogen and testosterone levels. [1]

That’s a long list of benefits, and it synergizes with vitamin D3 since it can prevent the breakdown of it. [2]

And now we get to the fun stuff.

Enhance features a mix of anabolic ingredients from BryoViron extract, to Korean mistletoe, KSM-66, longjack, PrimaVie and Safed Musli. 

One ingredient you probably haven’t seen before is Korean mistletoe. 

Korean mistletoe has been traditionally used in eastern medicine to enhance fat loss and fight diabetes. 

However it’s been added here for its ability to decrease muscle atrophy by inhibiting the atrogin-1 gene.

Safed Musli, another ingredient you may have seen a few times, is similar to tribulus. 

It’s standardized to 50% saponins, which is the bioactive compound that provides the benefits to this ingredient and tribulus has the same properties. 

Safed Musli is an adaptogen traditionally used in ayurvedic medicine to improve males health and sexual health. [34]

It also has anti-stress, antioxidant and immune improving properties. [56]

Since Huge Nutrition has labelled the standardization used, users know they are getting 50% saponins from safed musli extract. 

PrimaVie and longjack both play a role in testosterone production. 

PrimaVie is a high quality standardized extract and clinically studied form of shilajit from Natreon

Shilajit has several benefits including supporting healthy testosterone levels, energy, endurance, collagen and bone health. [7]

One study found participants taking 250mg of shilajit twice a day had higher levels of total and free testosterone levels while the placebo group had a decrease. [8]

Longjack contains various phytochemicals, ranging from quassinoids, tannins, alkaloids and triterpenes.

These phytochemicals are why longjack extract has anticoagulant, aphrodisiac, antioxidative, antibacterial, anxiolytic, and much more. [9]

A number of studies have found taking 100mg of longjack for five weeks increased lean body mass, muscle size and strength. [10]

Ashwagandha is known to be a stress killer because of its ability to significantly decrease cortisol levels, in fact it does this so well that it’s known to perform as well as some pharmaceutical drugs as it doesn’t have any side effects. 

Increase cortisol levels can decrease testosterone levels. 

Lowering cortisol levels will help increase testosterone levels and optimize it’s production. [1112]

One study had participants take 600mg of ashwagandha for 8 weeks and they found them to have 15% higher testosterone levels than the placebo group. 

And luckily, Huge Nutrition is using the high quality patented extract of ashwagandha, KSM 66 and the full clinical dose of 600mg. 

Clinically dosed formula
Increases strength and enhances recovery
Contains male enhancing compounds
Optimizes testosterone



Laxogenin is an interesting compound.

It’s a natural steroidal compound found in green plants and in supplements, it’s promoted as an natural anabolic agent to increase testosterone and strength levels without any side effects. 

Studies have found this compound to have anabolic activities without side effects. [13]

Meaning it can enhance testosterone production, lean mass, and strength without the acne, hair loss or aggression. 

It’s often compared to anavar because it has similar anabolic and androgenic ratings. While this isn’t backed by research, Laxogenin does seem to promote protein synthesis and reduce protein breakdown. [1415]

Users report anecdotally that taking 100-150mg is decent for strength and muscle gains. 

Or if you want something more potent and has Laxogenin, check out Sapogenix

Increases performance and muscle growth
Creates an anabolic environment for muscle growth



Epitech is made of 3 ingredients, the first one being epicatechin. 

This ingredient is one of the best muscle building ingredients for natural lifters because of it’s ability to inhibit a myokine myostatin. 

Myostatin is a myokine that can suppress muscle growth. One human study found that epicatechin has been found to decrease this 16% while increasing follistatin by 50%. 

Follistatin can increase muscle growth, and epicatechin has been found to increase follistatin by as much as 50%. 

While that particular study did not measure lean mass changes, it still shows promising potential. 

Another study in 2015 had participants take anywhere from 50-200mg of epicatechin had no side effects and compared to day 1 epicatechin users, the users who had been taking epicatechin for 5 days had 2.5 times more follistatin levels. 

It’s possible to get epicatechin from food but you wouldn’t be able to get much without consuming a lot of calories. 

To get 60-70mg of epicatechin, you would need to eat 200 calories worth of dark chocolate, and the chocolate would have to be 85% cocoa, like Lindt’s chocolate (not processed with alkali or Dutch process).

Improves muscle growth
Best way to get Epicatechins
Increases pumps



For bodybuilding, arachidonic acid is an exciting compound because of it’s promise to increase protein synthesis and muscle size. 

Taking 1.5g of ArA (arachidonic acid) has been shown to help to increase lean mass, strength and overall power. 

ArA is a omega 6 fatty acid found in the phospholipids of a body’s cells. It increases the production of eicosanoids of signaling molecules that control inflammatory and immunity pathways. 

The more ArA in the body, the more eicosanoids are produced and the more inflammation is made. 

Systemic inflammation over a long period of time is bad but a cycle of ArA will increase inflammation of muscle tissue of where it’s directed. 

It also works as a potent vasodilator. [16]

ArA helps increase the production of metabolites, the ones we’re interested in are the prostaglandins. 

Both Prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2 alpha) are increased with ArA supplementation. 

PEGF2 can enhance muscle growth by increasing protein synthesis. [1718]

Arachidone contains the exact dosage used in the clinical studies, 1.5g, making the perfect choice for muscle building. 

Enhances lean mass and strength
Increases inflammation to targeted muscles
Prolongs nitric oxide production and pumps

Final Words

At this point, you probably should have an idea of what muscle-building stack to get. 

It’s more than difficult to gain mass but thanks to clinical research, Huge Nutrition has formulated effective stacks for mass building. 

Once you decide on a stack, like Huge Mass, you should stay on it for at least 4-8 weeks to get the best results, with 8 weeks being the ideal amount of time.

Your diet and program should be on point, and if it’s not, then supplements are generally going to be a waste of time and money. 

If you’re struggling with diet and exercise, check out this section

Using one potent supplement will do just fine but if you combine it and use it as a stack it'll be very effective at building muscle. 


What is a supplement stack?

A supplement stack is a group of supplements that work together to enhance your performance, recovery, and muscle-building potential. They often include a combination of protein, creatine, BCAAs, and pre-workout supplements.

Why should I consider using a supplement stack for lean muscle mass?

Supplement stacks are designed to maximize your workouts and speed up recovery. They can provide the necessary nutrients your body needs to build and maintain lean muscle mass.

Are supplement stacks safe?

Most supplement stacks are safe as long as they are used as directed. However, it's always best to consult with a healthcare provider before starting any new supplement regimen.

Can I create my own supplement stack?

Yes, you can create your own supplement stack. However, it's important to do your research and understand how different supplements work together. It's also recommended to consult with a healthcare provider or a nutritionist.

How long does it take to see results from a supplement stack?

The time it takes to see results from a supplement stack can vary depending on your diet, workout routine, and the supplements you're taking. However, most people start to see results within a few weeks.

Are there any side effects of supplement stacks?

Side effects can vary depending on the supplements included in the stack. Some common side effects can include digestive issues, sleep disturbances, and dehydration. Always follow the recommended dosage and consult with a healthcare provider if you experience any adverse effects.

Can women use supplement stacks for lean muscle mass?

Yes, there are supplement stacks specifically designed for women. These stacks are formulated to support women's unique nutritional needs and fitness goals.

Do I need to take my supplement stack every day?

The frequency at which you should take your supplement stack depends on the specific supplements in your stack. Some supplements are meant to be taken daily, while others are meant to be taken only on workout days. Always follow the instructions provided with your supplement stack.

Can I use supplement stacks if I'm a vegan?

Yes, there are vegan-friendly supplement stacks available. These stacks use plant-based proteins and other vegan-friendly ingredients.

What should I do if I'm not seeing results with my supplement stack?

If you're not seeing results with your supplement stack, it may be worth reviewing your diet and exercise routine. It's also possible that the stack you're using isn't the best fit for your goals. Consider consulting with a nutritionist or personal trainer for personalized advice.

What is the best supplement stack for beginners? 

The Kaged Training Stack is recommended for beginners. It includes a pre-workout, protein powder, hydration support supplement, and a creatine supplement.

What is third-party testing in supplement stacks?

 Third-party verification is a very important aspect of the supplement industry. Since FDA regulations around supplements are so lax, other organizations have stepped up to ensure a safer supplement scene. This includes Certificates of Analysis (CoAs), National Sanitation Foundation certification, NSF Safe for Sport, Good Manufacturing Practices verification, and US Pharmacopeia Verified Mark.

by Nader Qudimat

Forged by the iron and cold steel, Nader takes his knowledge and hulks it up into this site.

Having to be stuck as a 110lb skinny guy in the early days, he has had no choice but to keep improving himself until he cannot.

Click here to check out his 12 year transformation: Natural 12 Year Transformation

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