1-Andro Guide: Gains, Sides and Cycles, Is The Price Worth It?

by Nader Qudimat
Updated November 2, 2021
Muscle Builder
Serving Size
Easy to find
Fully disclosed supplement
Strengthens muscle tendons
Price is a bit high

Bottom Line

1-Andro is known as a potent prohormone. 

It promises to improve lean mass, increase strength and performance without the side effects. 

It's short for 1-Androsterone (1-DHEA) and although it's marketed to be safe, there's still some side effects associated with it. 

Similarly, 4-Andro is also another DHEA-based prohormone that is commonly used alongside 1-Andro.

I would recommend Sapogenix or Annihilate as a alternative to 1-Andro for potent gains without the side effects.

Or even Ecdysterone

1-DHEA, or 1-Andro is suppose to be one of the most potent prohormones available.

It's a hot seller in the prohormone category.

Users report of gains from 6-8lbs within 2 months without the nasty side effects. 

Compared to other options, like Sapogenix or Annihilate, or even the stacks that Huge Nutrition sells would be a better route to go, not only for the gains but also for the safety of your health. 

The reason why 1-DHEA is popular is because it can increase muscle size similarly to steroids. 

It can be converted into hormones that are beneficial for muscle gains. 

But what about the side effects?

Let's dig into 1-Andro…


What 1-DHEA is known for is having no side effects and strong benefits for muscle building. 

It's a legal prohormone, and so far, it's still available for sale. 

And it's typical to hear users gaining anywhere from 5-lb to 10lb within 2 months. 

Some of that could be fat of course, I don't think you can gain muscle without gaining a bit of fat. 

While this isn't toxic to the liver, it can still suppress your natural hormone production. 

So a PCT like Rebirth is recommended.

1-Andro vs 4-Andro

These two are both muscle builders, 4-DHEA and 1-DHEA, but what is the difference between them? 

While they are both synthetic non-methylated prohormones, they are different in what they offer.

1-DHEA is geared towards more muscle building and increasing strength, while 4-DHEA is for increasing sex drive, libido and improving recovery. 

The stronger prohormone is 1-Andro as it can convert into both 1-androstenediol and 1-androstenedione. 

Nor 1-DHEA or 4-DHEA will convert into estrogen.

What is a Prohormone and Why is DHEA One?

The reason why is because 1-Andro is a anabolic androgenic steroid, it's partly organic and half synthetic. 

It can affect your hormone production, strength, and even your appetite. 

While 1-Andro is much more mild than the hardcore prohormones, it's still recommended to take a PCT.

When 1-Andro is consumed, it converts into 1-testosterone. 

But 1-testosterone doesn't cause serious side effects that you would typically get from stronger prohormones like acne, testies shrinking, mood swings etc. 

While it is safer than steroids, we would recommend Sapogenix because it's much better for strength and muscle without any side effects at all.

Benefits of 4-Andro and 1-Andro

Since 4-Andro and 1-Andro are similar in potency, we'll talk about the benefits for both here. 

Starting with 1-Andro, the benefits for this includes:

  • Increases lean muscle mass
  • Improves recovery
  • No typical side effects like steroids
  • No increase in estrogen
  • Improves fat loss and muscle density

You can see why 1-Andro would be popular on paper, but in real life, it isn't as potent as the other options out there that don't even have side effects. 

For 4-Andro here are the benefits:

  • Increases libido and sex drive
  • Non-methylated, no toxicity on liver
  • Improves muscle growth by increasing muscle protein synthesis
  • Improves recovery
  • Uplifts mood
  • Increases strength 

You can see why 4-Andro is popular, because it's safe on the liver and it doesn't have the typical side effects that stronger prohormones have. 

1-DHEA Side Effects

With prohormones, comes side effects. 

And the issue of 1-Andro is that there's very little research done on it. 

In fact, only one study has been conducted and they found good and bad effects of 1-Andro.

They found increase lean mass, lowered fat mass, and more strength.

But at the cost of higher “bad” cholesterol levels, and damaged organ function (kidney and liver).

You should use a PCT like Rebirth PCT to avoid or minimize the side effects. 

It's difficult to avoid these side effects and it generally doesn't happen  unless you're using more than the recommended dose, not following the label's directions or cycling through. 

While 1-Andro doesn't increase estrogen, 4-Andro does slightly. 

And some other side effects that 1-Andro can bring:

  • Stress and anxiety increase
  • Lowered libido
  • Hair loss
  • Elevated blood pressure
  • Back pumps
  • Can stay in the body for few days after ending cycle

And for 4-Andro:

  • Increases aggression and mood swings
  • Elevates blood pressure
  • Back pumps and muscle cramps
  • Enlarged breasts

There isn't any liver toxicity so 1-Andro and 4-Andro are safe.

But it would be wise to take some on-cycle supplement or a PCT to ensure full protection. 

While these side effects are not common, we recommend trying any of these legal steroids, or just go for Sapogenix, a natural plant-steroid mix of anabolics. 

4-Andro and 1-Andro Cycles

Typically, either or both 1-Andro and 4-Andro are used for 4-8 weeks. 

But with 4-Andro, you may experience elevated blood pressure. 

That's why it's essential to include some form of a on-cycle supplement or PCT.

Since your making your body make more hormones while taking DHEA, it's possible to experience the side effects listed above. 

That's why it's important to have a PCT ready to prevent any hormone imbalances and to maximize your test production after the cycle. 

There should be a 6-12 week break after a cycle is finished. 

1-Andro and 4-Andro Supplements

The most popular and best 1-Andro supplement is Hi-Tech 1-Testosterone. 

It's made by Hi-Tech Pharmaceuticals and each pill has 115mg of 1-Andro.

If you're taking the recommended dose of 600mg of 1-Andro per day, then this bottle would last you about 12 days. 

You would need at least 4 bottles to complete a 6 week cycle. 

This can get expensive but that's why they added cyclosome delivery to their formula which should help with the bioavailability of the ingredients. 

1-Testosterone is an expensive choice, we would recommend checking out Sapogenix instead. 

If you still go with 1-Testosterone then use a PCT supplement

The next prohoromone is Brutal 4CE, by Blackstone Labs.

This is a 4-Andro product and it's the best you can get. 

It elevates testosterone levels, increases muscle gain and it isn't toxic for the liver. 

Blackstone Labs includes liposomal delivery to help increase the bioavailability and absorption of the 4-Andro compound. 

Each capsule contains 65mg which is kind of low, as you would need to take 5 pills to get to 325mg.

This would turn the price up really quick. 

But it does contain 3 forms of 4-Andro forms. 

We would recommend Sapogenix or using one of the legal steroids listed here instead. 

Absorption of 1-Andro and 4-Andro

The most expensive and perhaps the worst absorbing forms of 1-Andro and 4-Andro can be found in most supplements. 

The reason for this is because DHEA is notorious for having poor bioavailability. 

Both Blackstone Labs and Hi-Tech included some delivery system that enhances absorption of the DHEA compounds. 

Using cyclodextrin helps with absorption, we would trust Hi-Tech and Blackstone labs to do better as they have been creating supplements like this for decades.

The other downside is the price. 

Most supplements with 1-Andro and 4-Andro are almost always more expensive than 1-Testosterone and Brutal 4CE. 

And you can even make it cheaper by using our discount code FITFREK.

Consider the Alternatives

This just got real…

I'm sure you're sick of these protein powders.

Mass gainers are supposed to help you put on weight with quality calories.

But most mass gainers are just plain useless.

They do help put on weight but 99.9% of that weight will be fat.

And most weight gainers spike up their protein calculation count with amino acids (you'll find out more below).


Both 1-Andro and 4-Andro are potent prohormones. They are safe for the organs but the gains aren't worth the price. Try out Sapogenix instead.

by Nader Qudimat

Forged by the iron and cold steel, Nader takes his knowledge and hulks it up into this site.

Having to be stuck as a 110lb skinny guy in the early days, he has had no choice but to keep improving himself until he cannot.

Click here to check out his 12 year transformation: Natural 12 Year Transformation

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