Prohormones vs SARMs: Which Is More Effective?

by Nader Qudimat
Updated July 20, 2023

Welcome to the world of anabolics, where selective androgen receptor modulators (SARMs) and prohormones are at the top of the chain.

These supplements are not just popular; they challenge real anabolics like steroids and testosterone.

But what sets them apart?

Let's dive in.

Prohormones vs. Sarms Quick Comparison:

SARMs and prohormones have been developed by dedicated companies, each with its unique approach. While serving a similar purpose, these supplements have distinct mechanisms of action.

SARMs, known for their selective action, target specific tissues, leading to fewer side effects.

On the other hand, prohormones, precursors to active hormones, offer faster results but with a higher risk of side effects.

SARMs Overview:

Selective Androgen Receptor Modulators (SARMs) selectively bind to androgen receptors, leading to anabolic cellular activity while avoiding many side effects of currently available anabolic steroids.

This makes them a promising therapeutic option for a variety of conditions.

SARMs have been studied for their potential use in treating conditions such as breast cancer, cachexia (a condition involving physical wasting with loss of weight and muscle mass), and hypogonadism (a condition in which the body doesn't produce enough testosterone).

They have also been used as performance-enhancing agents.

SARMs work by differentially binding to androgen receptors depending on each SARM's chemical structure.

This results in tissue-selective activation of androgenic signaling.

This means that they can have different effects in different tissues, which can be beneficial for targeting specific conditions or symptoms.

While there are currently no FDA-approved indications for SARMs, researchers are exploring their potential uses.

Early clinical studies have shown promising results.

SARMs demonstrate potential uses in treating cancer-related cachexia, benign prostatic hyperplasia (a condition in which the prostate gland becomes enlarged), hypogonadism, and breast and prostate cancer.

However, it's important to note that while SARMs have numerous potential clinical applications, they also come with risks.

These risks need to be carefully weighed against the potential benefits when considering the use of SARMs for any given condition.

For more detailed information, you can refer to this source.

Read our guide on SARMs here.

Prohormones Overview:

Prohormones are precursors to hormones typically used in the bodybuilding community for their potential muscle-building effects.

They are converted into active hormones, such as testosterone or nortestosterone, through enzymatic processes.

Prohormones have been a popular practice, despite a relative lack of information on their effects.

Unlike synthetic anabolic-androgenic steroids, many of these over-the-counter androgens are produced endogenously by adrenal, gonadal, and peripheral steroidogenic pathways as part of the normal sexual and reproductive hormonal milieu.

It has been suggested that the peripheral enzymatic conversion of these prohormones to testosterone or nortestosterone might lead to anabolic and/or ergogenic effects.

However, existing data suggest that oral supplementation with prohormones has no significant effect on body composition or physical performance.

For instance, supplementation with androstenedione or androstenediol has not affected body composition or physical performance, even with doses of up to 300 mg/day for as long as 12 weeks.

Similarly, supplementation with nor androstenedione and nor androstenediol for up to eight weeks has also been shown to not affect body composition or physical performance.

In light of these findings, the risk-to-benefit ratio of using these substances orally seems unfavorable.

Therefore, while prohormones may seem attractive for those looking to enhance their physical performance or muscle mass, it's important to consider the potential risks and lack of proven benefits.

For more detailed information, you can refer to this source.

Our guide to prohormones can be found here.

Comparison Of SARMs And Prohormones:

When comparing SARMs and prohormones, it's essential to look at their ingredients and the effects of those ingredients.

For instance, SARMs like ostarine are known for their muscle-preserving effects, making them a popular choice for bodybuilders during cutting cycles.

On the other hand, prohormones like epistane are favored for their potent muscle-building effects.

Pros And Cons:

Like any supplement, SARMs and prohormones have their pros and cons. SARMs are generally considered safer with fewer side effects, but their muscle-building effects may not be as potent as prohormones.

While effective for muscle building, prohormones come with a higher risk of side effects and potential legal issues.

Performance Comparison:

With performance, the choice between SARMs and prohormones depends on your goals.

Prohormones might be the way to go if you're looking for potent muscle-building effects and are willing to manage the potential side effects.

However, if you're looking for a safer alternative with fewer side effects, SARMs could be a better choice.

Prohormones vs SARMs: Side Effects

With side effects, both SARMs and prohormones have their own set of potential issues.

Prohormones, due to their conversion into active anabolic steroids in the body, can have severe side effects.

These can include liver stress, negative cholesterol changes, gynecomastia (male breast enlargement), and suppression of natural testosterone production, which can lead to issues like testicular shrinkage and infertility source.

On the other hand, SARMs are generally considered to have fewer side effects than prohormones.

They are selective in their action, targeting specific tissues and less likely to cause unwanted side effects.

However, they are not entirely free from potential issues.

Some users have reported experiencing testosterone suppression, mood, and vision changes when using SARMs.

It's also worth noting that long-term effects of SARMs use are still not fully understood due to the lack of long-term clinical trials source.

Prohormones vs SARMs: Effectiveness

The effectiveness of prohormones and SARMs can vary greatly depending on the specific compound used, the dosage, the duration of use, and the individual's response.

Prohormones are known to be quite effective for increasing muscle mass and strength.

However, their use can come with significant side effects and health risks source.

SARMs, on the other hand, are designed to target muscle and bone tissue selectively.

This can increase muscle mass and bone density without the side effects of prohormones and anabolic steroids.

However, the effectiveness of SARMs can vary, and some users may not experience the same level of results as with prohormones source.

Prohormones vs SARMs: Cost

The cost of prohormones and SARMs can vary greatly depending on the specific compound, the brand, and where you purchase them.

In general, SARMs tend to be more expensive than prohormones.

This is due in part to the complex process required to produce SARMs, and their growing popularity and demand source.

Prohormones vs SARMs: Legality

The legality of prohormones and SARMs can vary depending on your location.

In the United States, most prohormones are classified as controlled substances, making them illegal to sell or possess without a prescription.

SARMs, on the other hand, are not currently controlled substances, but they are considered unapproved drugs by the FDA, making it illegal to sell them for human consumption source.

Prohormones vs SARMs: Stacking

"Stacking" refers to using multiple supplements or drugs together to enhance their effects.

Both prohormones and SARMs can be stacked, but this practice increases the risk of side effects and can be dangerous without proper knowledge and supervision.

It's always recommended to do thorough research and consult with a healthcare professional before starting any new supplement regimen source.


What are SARMs and how do they work?

Selective Androgen Receptor Modulators (SARMs) are a drug that can selectively stimulate the androgen receptors in certain tissues, such as muscle and bone. They work by binding to androgen receptors, leading to anabolic activity that promotes muscle growth and repair. This selective action can result in fewer side effects than traditional anabolic steroids source.

What are prohormones and how do they work?

Prohormones are precursors to active hormones. When ingested, the body processes these compounds into an active hormone, such as testosterone or another anabolic steroid. This conversion process typically occurs in the liver source.

What are the potential benefits of SARMs?

SARMs have been studied for their potential use in treating conditions such as cachexia (a wasting syndrome that causes severe weight loss and muscle atrophy), benign prostatic hyperplasia (an enlarged prostate), and certain types of cancer. However, more research is needed to fully understand their potential benefits and risks source.

What are the potential risks of using SARMs?

While SARMs are generally considered to have fewer side effects than traditional anabolic steroids, they are not without risks. Potential side effects can include changes in mood, liver damage, and cardiovascular issues. It's also important to note that the use of SARMs is currently banned in many sports due to their performance-enhancing effects source.

What are the potential risks of using prohormones?

Like SARMs, prohormones can also have side effects. These can include liver damage, changes in mood, and cardiovascular issues. Additionally, because prohormones are converted into anabolic steroids in the body, they can have many of the same side effects as these substances, including acne, hair loss, and an increased risk of certain cancers source.

Are SARMs legal?

Currently, there are no FDA-approved indications for SARMs, and their sale is prohibited in many countries. However, they are often sold online as "research chemicals" source.

Are prohormones legal?

The legality of prohormones can vary depending on the country. In the United States, many prohormones were banned with the Anabolic Steroid Control Act of 2004 and 2014. However, some prohormones are still legal and available for purchase source.

Can SARMs and prohormones be detected in drug tests?

Yes, both SARMs and prohormones can be detected in drug tests. Many sports organizations test for these substances due to their performance-enhancing effects source.

What is the difference between SARMs and prohormones?

The main difference between SARMs and prohormones lies in their mechanism of action. SARMs selectively bind to androgen receptors, leading to anabolic activity in certain tissues. On the other hand, prohormones are converted into active anabolic steroids in the body source.

Which is better: SARMs or prohormones?

The answer to this question can depend on a variety of factors, including the individual's specific goals, their health status, and their tolerance for risk. Both SARMs and prohormones have potential benefits and risks, and it's important to thoroughly research and consider these before deciding to use either source.

Bottom Line

Choosing between SARMs and prohormones is a personal decision that should be based on your individual needs and goals.

Both have their unique benefits and drawbacks, and what works best for one person might not work as well for another.

Always research and consult with a healthcare professional before starting any new supplement regimen.

by Nader Qudimat

Forged by iron and cold steel, I'm Nader, a mid-30s natural bodybuilder. Once a 100lb skinny guy, I've transformed into a 200lb muscular athlete with over 15 years of lifting experience. Today, I leverage my transformation and extensive experience to guide countless individuals on their fitness journeys.

Click here to check out my 12 year transformation: Natural 12 Year Transformation

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