Nitrosigine vs Arginine: Which Is More Effective?

by Nader Qudimat
Updated July 3, 2023

You've probably heard about Nitrosigine and L-Arginine.

These two ingredients are often found in pre-workout supplements, and they're known for their potential to enhance performance.

But which one is more effective?

That's what we're going to explore in this article.

Nitrosigine And L-Arginine: A Quick Rundown

Nitrosigine is more effective than L-Arginine in several aspects, particularly enhancing workout performance and promoting muscle pump.

Nitrosigine is more bioavailable and effective in boosting nitric oxide levels, leading to better pumps and performance.

Understanding Nitrosigine

Nitrosigine, also known as inositol-stabilized arginine silicate, is a patented ingredient trending with pump supplements.

But what makes it so special?

First, Nitrosigine is known for its ability to boost nitric oxide levels in the body.

This is crucial for athletes and fitness enthusiasts, as nitric oxide plays a key role in vasodilation - the widening of blood vessels.

This can improve blood flow, better nutrient delivery to muscles, and enhanced performance.

But don't just take our word for it.

Several studies back up these claims.

For instance, a study published in the Journal of the International Society of Sports Nutrition found that Nitrosigine significantly increased nitric oxide levels in participants, improving muscle pumps during workouts.

Read here to learn more about Nitrosigine.

Understanding L-Arginine

On the other hand, we have L-Arginine, an amino acid that's been a staple in pre-workout supplements for years.

Like Nitrosigine, L-Arginine is also known for boosting nitric oxide levels.

However, there's a catch.

While L-Arginine does increase nitric oxide, its bioavailability when taken orally is relatively low.

This means that not all of the L-Arginine you consume will be used by your body - some of it will be excreted.

But that's not to say L-Arginine is useless.

When absorbed, L-Arginine can offer several benefits, such as improved blood flow, better nutrient delivery, and enhanced performance, much like Nitrosigine.

However, the effectiveness of L-Arginine as a pre-workout supplement has been debated.

While some studies have found positive effects, others have found little benefit.

For instance, a study published in the Journal of Dietary Supplements found that L-Arginine supplementation did not significantly improve performance in trained runners.

Nitrosigine vs Arginine: Comparative Analysis


Both Nitrosigine and L-Arginine have been shown to boost nitric oxide levels in the body effectively.

However, some studies suggest that Nitrosigine may be more effective than L-Arginine.

For instance, a study found that Nitrosigine was more effective in increasing nitric oxide production and enhancing blood flow than L-Arginine.


Both supplements are generally considered safe for most people.

However, they can cause some side effects.

In some people, L-Arginine can cause abdominal pain, bloating, diarrhea, and allergies.

On the other hand, Nitrosigine can cause mild side effects like nausea, headache, and dizziness.

It's important to note that these side effects are usually mild and go away independently.


The cost of these supplements can vary widely depending on the brand, dosage, and where you buy them.

Generally, L-Arginine supplements tend to be less expensive than Nitrosigine.

However, considering the potential increased effectiveness of Nitrosigine, it may provide better value for money.

How To Choose Between Nitrosigine And L-Arginine

Choosing between Nitrosigine and L-Arginine ultimately comes down to your personal goals and fitness level.

If you're looking for a proven and effective option, Nitrosigine is the way to go.

Its superior bioavailability means that more of it is used by your body, leading to better results.

While L-Arginine is generally more affordable, its effectiveness when taken orally is a topic of debate. Many studies suggest that it may not be effective at all for enhancing workout performance.

Therefore, despite its lower cost, it may not provide the results you're looking for.

It's also important to consider potential side effects and contraindications.

While Nitrosigine and L-Arginine are generally safe, they can cause side effects in some people, such as stomach discomfort or changes in blood pressure.

The Power Of Nitrosigine

Nitrosigine is a patented complex of arginine and silicon clinically shown to boost nitric oxide (NO) levels, promoting healthy blood vessels and enhancing blood flow.

This is particularly beneficial for athletes and bodybuilders as enhanced blood flow can lead to better nutrient delivery, improved oxygen flow, and more efficient removal of waste products like lactic acid and ammonia.

Nitrosigine And Cognitive Function

A study published in the Journal of the International Society of Sports Nutrition found that Nitrosigine supplementation improved cognitive function in subjects who engaged in strenuous exercise.

This is a significant finding, as cognitive function often declines during and after intense workouts.

By improving cognitive function, athletes and fitness enthusiasts may be able to maintain focus and concentration during their workouts, leading to better performance.

Nitrosigine And Muscle Pump

Nitrosigine can enhance muscle pump during workouts.

Muscle pump refers to the temporary increase in muscle size when you lift weights, especially during high-volume, high-rep training.

This is due to increased blood flow to the working muscles, which delivers oxygen and nutrients that fuel muscle contractions.

Enhancing muscle pumps allows Nitrosigine to make your workouts more effective and satisfying.

Arginine Nitrate: A Different Beast

Arginine Nitrate is a compound that combines the amino acid arginine with nitrate – a potent nitric oxide booster.

This compound offers several benefits, including improved blood flow, heightened nitric oxide production, amplified energy levels, boosted strength and power, enhanced recovery, increased endurance, and even sexual performance enhancement.

Arginine Nitrate And Nitrosigine: A Comparison

Both Arginine Nitrate and Nitrosigine supplementation resulted in greater nitric oxide availability compared to a placebo.

However, when L-arginine was added to nitrate supplementation, there were no additional effects on nitric oxide biomarkers.

This suggests that L-arginine may not induce any performance-enhancing effect in elite endurance athletes, as per the findings of this study.

Exercise Economy And Endurance Performance

The study found no alteration in exercise economy or endurance running performances in endurance-trained cross-country skiers with either Arginine Nitrate or Nitrosigine supplementation.

This indicates that elite athletes with a healthy daily nutrition combined with high dosages of endurance training may not alter physiological responses or endurance performance with acute supplementation of nitric oxide donors.

Sprint Performance

Interestingly, the study found slightly better sprint performance with nitrate supplementation compared to the combination with L-arginine and nitrate.

The reasons for this are unclear and require further examination.

The Bottom Line On Arginine Nitrate vs Nitrosigine

Overall, the study suggests that the training status of the subjects is an important factor linked to the performance-enhancing effect of nitric oxide.

The absence of performance-enhancing effects of increased nitric oxide availability in endurance-trained athletes may be explained by the physiological and metabolic adaptations derived from chronic physical training.

However, potential dietary effects on elite athletes are small and positive individual responses that this study could not detect may still occur.

More studies are required to explore whether nutritional supplementations can increase nitric oxide availability and enhance performance in other elite athlete groups, exercise modes, hypoxic environments, or with chronic supplementation.

L-Arginine: The Precursor

L-arginine is an amino acid found in red meat, poultry, fish, and dairy.

It is necessary for making proteins and is commonly used for circulation.

L-arginine is converted in the body into a chemical called nitric oxide, which causes blood vessels to open wider for improved blood flow.

L-arginine also stimulates the release of growth hormones, insulin, and other substances.

In the next section, we'll dive deeper into the benefits of these ingredients and how they can enhance your workout performance and overall health.## Nitrosigine: The Superior Choice

According to a study published on NutraIngredients-USA, Nitrosigine was more effective than arginine hydrochloride in boosting arginine levels.

This is a significant finding because arginine is a precursor to nitric oxide, which helps relax and open up blood vessels, allowing for increased blood flow.

The study found that Nitrosigine increased arginine levels for a longer period, potentially leading to better performance during workouts.


What is Nitrosigine?

Nitrosigine is a patented ingredient often found in pre-workout supplements. It's known for its ability to boost nitric oxide levels, leading to improved blood flow and performance.

What is L-Arginine?

L-Arginine is an amino acid that's been a staple in pre-workout supplements for years. It's known for its ability to boost nitric oxide levels, but its effectiveness when taken orally is a topic of debate.

Which is more effective, Nitrosigine or L-Arginine?

Based on current research, Nitrosigine appears more effective than L-Arginine in boosting nitric oxide levels and enhancing performance, thanks to its superior bioavailability.

Are there any side effects to Nitrosigine or L-Arginine?

Nitrosigine and L-Arginine are generally safe, but they can cause side effects in some people, such as stomach discomfort or changes in blood pressure. Always consult with a healthcare professional before starting any new supplement regimen. Read more about the safety of Nitrosigine.

Which one should I choose, Nitrosigine or L-Arginine?

If you're looking for a proven and effective option, Nitrosigine is the way to go. While L-Arginine is more affordable, its effectiveness when taken orally is questionable, and it may not provide the results you're looking for.

Bottom Line

When comparing Nitrosigine vs L-Arginine, Nitrosigine appears to be the more practical option for boosting nitric oxide levels and enhancing performance.

However, L-Arginine is a more affordable and well-established ingredient without much evidence for effectiveness when taken orally.

We recommend going with Nitrosigine as it's much more effective.

by Nader Qudimat

Forged by iron and cold steel, I'm Nader, a mid-30s natural bodybuilder. Once a 100lb skinny guy, I've transformed into a 200lb muscular athlete with over 15 years of lifting experience. Today, I leverage my transformation and extensive experience to guide countless individuals on their fitness journeys.

Click here to check out my 12 year transformation: Natural 12 Year Transformation

Search This Site

About FitFrek

FitFrek operates as an independent platform, offering comprehensive workouts, programs, routines, guides, and unbiased reviews to accelerate your progress. We pride ourselves on our honesty, delivering straightforward and candid insights. FitFrek does not offer medical advice, diagnosis, or treatment services.

FitFrek © 2013 – 2024 All Rights Reserved
Exclusive Site of Nader Qudimat
linkedin facebook pinterest youtube rss twitter instagram facebook-blank rss-blank linkedin-blank pinterest youtube twitter instagram