Nitrosigine Guide: What Is It?

by Nader Qudimat
Updated July 1, 2023

Nitrosigine, a patented complex of arginine and silicon, is making waves in fitness and health supplements.

This compound has been shown to significantly enhance nitric oxide levels, providing many benefits for physical and cognitive performance.

This article aims to provide a comprehensive overview of Nitrosigine, its benefits, usage, potential side effects, and comparison with other similar supplements.

What Is Nitrosigine: Quick Overview

As a unique blend of arginine and silicon, Nitrosigine boosts nitric oxide production, leading to enhanced blood flow and improved workout performance. Nitrosigine can match the vasodilation effects of Citrulline Malate, even at a significantly lower dosage.

What is Nitrosigine?

Nitrosigine, also known as inositol-stabilized arginine silicate, is a unique formulation that combines arginine, inositol, and silicon.

It is designed to boost nitric oxide levels in the body, which can benefit physical performance and cognitive function.

Nitrosigine enhances the body's nitric oxide production, a molecule that plays a crucial role in cardiovascular health and physical performance.

This study shows that Nitrosigine increases nitric oxide levels, which can lead to improved blood flow and nutrient delivery to muscles.

Check out our ultimate guide to pre-workout supplements.

Benefits of Nitrosigine

Nitrosigine has many benefits, from increased vasodilation to brain health. Let's dig into them...

Improved Blood Flow

One of the primary benefits of Nitrosigine is its ability to improve blood flow. This is due to its effect on nitric oxide production, a molecule that helps relax and widen blood vessels.

Research shows that Nitrosigine can significantly enhance nitric oxide levels, improving blood flow.

Enhanced Cognitive Function

Nitrosigine has also been linked to improved cognitive function.

By boosting blood flow, Nitrosigine can enhance the delivery of oxygen and nutrients to the brain, potentially improving cognitive performance.

This study suggests that Nitrosigine can enhance cognitive function, particularly in focus and mental flexibility areas.

Increased Energy Levels

Nitrosigine can also help increase energy levels by improving blood flow and nutrient delivery.

This can be particularly beneficial during exercise, where increased blood flow can help deliver more oxygen and nutrients to working muscles, potentially enhancing endurance and reducing fatigue.

Potential Impact on Muscle Volume

There is also some evidence to suggest that Nitrosigine may positively impact muscle volume.

One study found that Nitrosigine supplementation increased muscle volume in participants, although more research is needed in this area.

Research has shown that Nitrosigine can have a significant impact on muscle volume.

In a double-blind, placebo-controlled study, participants who were supplemented with Nitrosigine showed a significant increase in muscle volume compared to those who took a placebo.

This suggests that Nitrosigine could be a valuable supplement for those looking to increase muscle mass and improve their physique.

Nitrosigine vs Other Ingredients

How does Nitrosigine stack up against other ingredients? Let's break it down...

Comparison with Other Similar Ingredients

Compared to similar supplements like Arginine and Citrulline, Nitrosigine stands out for its superior absorption and effectiveness.

For instance, a study found that a small amount of Nitrosigine resulted in the same degree of improvement in vasodilation, blood flow, and nitric oxide levels as over five times as much Citrulline Malate.

Unique Benefits of Nitrosigine

One of the unique benefits of Nitrosigine is its ability to increase nitric oxide levels in the body, which can enhance blood flow, improve workout performance, and boost muscle growth.

Additionally, Nitrosigine has been shown to enhance cognitive function, providing a mental edge during workouts.

How to Use Nitrosigine

To maximize the benefits of Nitrosigine, you need to use it correctly.

Here's how:

Recommended Dosage

The recommended dosage of Nitrosigine can vary depending on individual needs and goals. However, most research studies have used a dosage of around 1.5 grams per day, taken 30 minutes before exercise.

When and How to Take It for Best Results

For best results, Nitrosigine should be taken approximately 30 minutes before exercise.

This allows the supplement to be absorbed and starts boosting nitric oxide levels. 

It can be taken with or without food, although some people may find it easier to take it with a small snack to prevent stomach discomfort.

Side Effects and Precautions

While Nitrosigine is relatively safe, everybody is different, and some may not react well. 

Possible Side Effects of Nitrosigine

While Nitrosigine is generally considered safe, some people may experience side effects such as stomach discomfort, bloating, and diarrhea.

If you experience any adverse effects, it's recommended to discontinue use and consult a healthcare professional.

Who Should Avoid it

Although Nitrosigine is safe for most people, certain individuals should avoid it.

This includes those with a known allergy to the ingredients in Nitrosigine, pregnant or breastfeeding women, and individuals with certain medical conditions such as liver disease or kidney disease.

Always consult with a healthcare professional before starting any new supplement.


What is Nitrosigine?

Nitrosigine is a patented complex of bonded arginine silicate scientifically engineered to deliver benefits essential to peak sports performance. It is a powerful and safe non-stimulant ingredient that has been clinically studied for safety and efficacy.

How does Nitrosigine work?

Nitrosigine increases nitric oxide levels in the blood, enhancing blood flow to the muscles. This improved blood flow can lead to better muscle pumps, increased energy levels, and enhanced cognitive function.

What are the benefits of Nitrosigine?

Nitrosigine offers several benefits, including improved blood flow, enhanced cognitive function, and increased energy levels. It can also have a potential impact on muscle volume.

How should I use Nitrosigine?

The recommended dosage of Nitrosigine varies, but doses of up to 1500mg per day are considered safe. Taking Nitrosigine as part of your pre-workout routine for optimal results is best.

Are there any side effects of Nitrosigine?

Nitrosigine is generally well-tolerated and safe for most people. However, as with any supplement, it's always best to consult a healthcare provider before starting any new supplement regimen.

How does Nitrosigine compare to other supplements like Arginine and Citrulline?

Nitrosigine is more effective than Arginine at increasing nitric oxide levels. Just 1.5g of Nitrosigine can rival the effects of 8g of Citrulline Malate, one of the leading ingredients for blood flow production.

Does Nitrosigine have any effect on testosterone levels?

Currently, no scientific evidence suggests that Nitrosigine directly affects testosterone levels. However, by improving workout performance and recovery, it might indirectly influence hormonal balance.

How long does it take for Nitrosigine to work?

Nitrosigine starts to increase energy levels in a single dose, and continues to show significant increases in energy over time. It lasts up to 6 hours in the blood.

Is Nitrosigine better than Arginine?

Nitrosigine is a novel patented source of inositol-stabilized arginine silicate that elevates nitric oxide levels in the blood more effectively than Arginine.

Can I take Nitrosigine every day?

Yes, Nitrosigine can be taken daily. It is a non-stimulant ingredient, meaning it does not lead to the common side effects of stimulant-based supplements. However, it's always best to follow the manufacturer's instructions or consult a healthcare provider.

Bottom Line

Nitrosigine is a powerful supplement that can enhance workout performance, boost muscle growth, and improve cognitive function.

Its unique ability to increase nitric oxide levels sets it apart from similar supplements.

However, as with any supplement, it's important to use Nitrosigine responsibly and consult a healthcare professional before starting a new supplement regimen.

by Nader Qudimat

Forged by iron and cold steel, I'm Nader, a mid-30s natural bodybuilder. Once a 100lb skinny guy, I've transformed into a 200lb muscular athlete with over 15 years of lifting experience. Today, I leverage my transformation and extensive experience to guide countless individuals on their fitness journeys.

Click here to check out my 12 year transformation: Natural 12 Year Transformation

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