Annihilate Review: Make Huge Gains With This 5a-Hydroxy Laxogenin Based Anabolic?

by Nader Qudimat
Updated November 2, 2021
Muscle Builder
Serving Size
2 Capsules
Excellent way to increase size and strength
Highly anabolic for bodybuilding
Best quality for Laxogenin

Bottom Line

Building muscle is hard. 

Annihilate makes it much more efficient.

This compound inside this supplement is actually one of the most promising we've seen for muscle building. 

We have all the data and science to back it up.

Annihilate is one of the best choices for Laxogenin supplements and we'll show you why. 

Use discount code FITFREK. 

When it comes to muscle building, you have quite a few choices to go with. 

But only really a few can make a big difference in your training. 

One of those is Annihilate. 

This is a Laxogenin based supplement that has been backed by research to improve size, strength, and gains. 

Annihilate comes from Huge Supplements, a Netherlands based company that creates highly anabolic products like Sapogenix, Ecdysterone and Rebirth PCT.

It's pushed as a natural plant anabolic to help build muscle mass, enhance strength, and increase muscle protein synthesis. 

Laxogenin is also known as 5-Alpha Hydroxy Laxogenin, and it's completely natural but very anabolic. 

You'll find out shortly if this is worth trying. 

Annihilate by Huge Nutrition

There's only one ingredient to Annihilate and that's Laxogenin, and it's dosed at 100mg. 

It contains 60 servings, which means you can either use 1-2 capsules, and it'll last you a minimum of a full month's supply. 

Typically, this is taken for 8 weeks, but most people do see gains with only 4 week cycles. 

The upside to Laxogenin is that it doesn't mess with your hormones, nor does it have any toxicity so it's safe to use for a few months at a time. 

Annihilate Anabolic Effects

The reason why Annihilate is so strong is because it contains Laxogenin

Laxogenin is a brassinosteroid, which is a plant hormone, and it's similar to animal steroid hormones in structure. 

Compared to prohormones and SARMs, Laxogenin is safe to use but it's very anabolic.

It has the attention of bodybuilders because it has similar anabolic and androgenic as Anavar, although it's not as potent, Laxogenin still does not have any side effects. 

In fact, Laxogenin is produced from the same plant steroid that's used as raw material for over 50% of synthetic steroids like testosterone, cortisone and progesterone. [1, 2]

But most supplements don't actually have Laxogenin, as 12 different supplements were analyzed and they were found to be contaminated with untested diosgenin. [3]

That's why Annihilate is our choice for Laxogenin as it comes from a trusted company that produce high quality supplements.. 

In one Russian study with rats performed long ago, they administered a brassinosteroid derivative similar to Laxogenin and found an increase in total weight and the protein content of the organs (liver, heart, kidneys) as well as the leg muscles were increased as well, without affecting the sex hormones or mimicking their effects. [4]

Another study used another plant brassinosteroid on rats and found they had increased their food intake, higher lean muscle mass, bigger leg muscles and increased physical fitness. They found with muscle cells,  they had reduced protein breakdown and higher protein synthesis.  [6, 7

Researchers have also found a class of plant chemicals with a structure similar to brassinosteroids / phytoecdysteroids (check out our review on Ecdysterone here), had increased muscle growth and protein synthesis in muscle cells. [8, 9, 1011]

These compounds are similar to Laxogenin and belong to the same family of plant-based steroids with similar chemical structures. 

And because there's a nice 100mg dose of Laxogenin in Annihilate, you'll sure to get more than enough to produce similar results to what the researchers have found in studies. 

Annihilate has the potential to:

  • Increase muscle protein synthesis
  • Reduce body fat
  • Prevent muscle breakdown
  • Increase size and mass
  • Reduce cortisol levels

Annihilate creates a very anabolic environment for the body to grow.

Since it may decrease cortisol levels, this will indirectly increase testosterone production. 

Annihilate on it's own will help with gains tremendously, I can't imagine what it would be like to stack with something as potent as Ecdysterone

How To Use Annihilate

The recommended use for Annihilate is to use it once in the morning, and another capsule in the evening. 

The best results come from using it for at least 8 weeks, optimally 12 weeks. 

You might find it effective at one capsule, but if you're looking to get the most out of your training, then you'll likely benefit the most from a full serving. 

But if you don't have a properly planned program and diet, you won't get the best results out of Annihilate. 

Are There Any Side Effects?

When it comes to side effects, the worst that can happen is headaches and an upset stomach. 

This usually occurs if you take too much Laxogenin. 

To avoid this, it's best to start with 1 capsule for 1-3 days, and if you feel fine, you can increase your dosage to 2 capsules. 

You're unlikely to feel any headaches if you drink enough water and have a proper diet. 

Best Anabolic Stack With Annihilate

Laxogenin on it's own will produce same really nice results. 

Imagine if it was stacked with another anabolic or two?

Most people stack Annihilate with Epicatechin because of it's synergy to promote muscle growth and size. 

The best epicatechin is Epitech because it has absorption enhancing ingredients to assist with bioavailability. 

Ecdysterone is another strong but natural anabolic that we recommend stacking Annihilate with. 

My Results with Annihilate

I'm currently using Annihilate and haven't finished it yet. 

As soon as I finish I will update this section and publish my review. 

For now, I recommend subscribing to the email newsletter to stay updated.

Where To Buy Annihilate?

The best source for Annihilate is

They are currently the only store that has this product and you can read the reviews of other users there.

We haven't found any users regretting using Annihilate yet. 

It's best used in the Huge Mass Stack.

Another option is the Insanity Stack if you're on a budget.

You'll find more users and reviews on the Huge Mass Stack, however, because of it's effectiveness.

Annihilate The Weights

Laxogenin has come this far and we haven't found any disappointed users yet. 

Annihilate is one of the best Laxogenin products, if not, the best, as it has just pure Laxogenin.

The only downside is when you purchase one bottle, you'll regret not getting another. 

Make the most out of your workouts and try out Annihilate. 

Use discount code FITFREK.

Annihilate For The Win

Annihilate is an amazing Laxogenin based supplement that is highly anabolic. It'll help you put on size and strength in a short period of time.

by Nader Qudimat

Forged by iron and cold steel, I'm Nader, a mid-30s natural bodybuilder. Once a 100lb skinny guy, I've transformed into a 200lb muscular athlete with over 15 years of lifting experience. Today, I leverage my transformation and extensive experience to guide countless individuals on their fitness journeys.

Click here to check out my 12 year transformation: Natural 12 Year Transformation

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