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Nitrosigine vs. Citrulline: Which Gives Better Pumps?

by Nader Qudimat
Updated July 1, 2023

L-Citrulline and Nitrosigine are two popular ingredients due to their ability to enhance nitric oxide production, improve blood flow, and boost exercise performance.

This article will delve into the benefits of these supplements, their impact on cardiovascular and metabolic health, and their recommended dosages.

Citrulline vs Nitrosigine: A Quick Comparison

Nitrosigine is more potent at smaller doses and can improve cognitive function, while Citrulline is known for boosting nitric oxide production and enhancing recovery. Both ingredients are potent and can be stacked together so the choice between the two will depend on your specific needs and goals.

Nitrosigine: A Potent Performance Enhancer

Nitrosigine, also known as inositol-stabilized arginine silicate (ASI), is a patented ingredient that has been shown to significantly enhance nitric oxide levels.

Nitric oxide is a molecule that helps relax and widen blood vessels, improving blood flow and oxygen delivery to working muscles.

(Read: Best Pump Supplements)

This makes Nitrosigine a popular supplement among athletes and fitness enthusiasts looking to improve their performance and recovery.

While both Nitrosigine and L-Citrulline can enhance nitric oxide production and improve exercise performance, there are some key differences between the two:

  • Bioavailability: Nitrosigine has been shown to have superior bioavailability compared to L-Citrulline. This means that a smaller dose of Nitrosigine is needed to achieve the same effects as a larger dose of L-Citrulline.

  • Duration of Action: Nitrosigine has been shown to increase nitric oxide levels for up to 14 days, while the effects of L-Citrulline are typically shorter-lived.

  • Safety Profile: Both Nitrosigine and L-Citrulline are generally well-tolerated and safe for most people. However, as with any supplement, it's important to consult with a healthcare provider before starting a regimen.

Dosage for Nitrosigine

The typical dosage for Nitrosigine is between 800mg to 1.5g per day, sometimes up to 1.6g. This can vary based on individual needs and tolerance.

Citrulline: The Health and Vasodilation Booster 

L-Citrulline is a non-essential amino acid that plays a crucial role in the urea cycle, a process that helps eliminate ammonia from the body. It also serves as a substrate for recycling L-arginine, a precursor for the synthesis of nitric oxide (NO). NO is a molecule that helps relax and widen blood vessels, improving blood flow and oxygen delivery to working muscles.

Health Benefits of L-Citrulline

  1. Blood Pressure Regulation: L-Citrulline has shown promise as a blood pressure-lowering intervention in adults with pre-/hypertension.
  2. Atherogenic-Endothelial Protection: There is pre-clinical (animal) evidence for atherogenic-endothelial protection through L-Citrulline supplementation.
  3. Muscle and Metabolic Health: Preliminary evidence is available for L-Citrulline-induced benefits to muscle and metabolic health in susceptible/older populations.

Dosage for L-Citrulline

The recommended dosage for L-Citrulline varies depending on the intended use:

  • For Sports Performance: The recommended dosage is between 6-8g about an hour before exercise. However, up to 10g can be used for sports performance. Anything higher may give diminishing returns of effects.
  • For Circulatory Health or to Alleviate Erectile Dysfunction: The recommended dosage is 2,000 mg of L-Citrulline, three times a day with meals, for a total daily dose of 6,000 mg. L-Citrulline does not need to be taken with meals.
  • For Circulatory Health with a Citrulline Malate Supplement: Take 1.76 g of citrulline malate for every 1 gram of L-Citrulline you would normally take.

L-Citrulline vs Nitrosigine: A Comparison

When comparing L-Citrulline and Nitrosigine, several factors come into play.

These include their mechanisms of action, health benefits, and recommended dosages.

  • Mechanisms of Action: L-Citrulline works by participating in the urea cycle and recycling L-arginine, a precursor for nitric oxide synthesis. On the other hand, Nitrosigine enhances nitric oxide levels directly.
  • Health Benefits: Both supplements offer cardiovascular benefits, but Nitrosigine also has cognitive benefits.
  • Recommended Dosages: The recommended dosage for L-Citrulline varies depending on the intended use, while the typical dosage for Nitrosigine is between 800mg to 1.5g per day.

Comparing How L-Citrulline and Nitrosigine Work

L-Citrulline and Nitrosigine play a significant role when enhancing your workout performance.

However, they do so in slightly different ways.

L-Citrulline

L-Citrulline is an amino acid that directly impacts your body's nitrogen balance. Here's how it works:

  • L-Citrulline is converted into L-arginine in the kidneys. This transformation is a crucial step in the process.
  • L-arginine becomes the building block for nitric oxide (NO), a compound significantly affecting your blood vessels.
  • As a vasodilator, NO relaxes and widens your blood vessels. This process allows for increased blood flow and oxygen delivery to your muscles.
  • The result is enhanced exercise performance and recovery, as shown in this study.

Nitrosigine

Nitrosigine, also known as inositol-stabilized arginine silicate, is a patented ingredient that boosts nitric oxide levels, much like L-Citrulline. Here's how it works:

  • Nitrosigine provides a source of arginine and silicon; two compounds are known to boost NO production and improve blood vessel health.
  • The silicon in Nitrosigine has an additional role - it helps strengthen and provide flexibility to your arterial walls.
  • This process promotes better blood flow and cardiovascular health, as research shows.

Similarities and Differences

While both L-Citrulline and Nitrosigine boost nitric oxide levels and improve blood flow, they do so through different mechanisms. L-Citrulline relies on a transformation process in the kidneys, while Nitrosigine provides direct sources of arginine and silicon.

The key similarity between the two is their end goal - to enhance exercise performance and recovery by improving blood flow and oxygen delivery to the muscles.

However, Nitrosigine has the added benefit of strengthening and providing flexibility to arterial walls, which can further improve cardiovascular health.

Ultimately, both L-Citrulline and Nitrosigine have unique benefits and mechanisms of action, making them valuable additions to a pre-workout supplement.

Benefits of Nitrosigine

Nitrosigine, a patented complex of arginine and silicon, has been shown to offer several benefits, particularly for those engaged in regular physical activity.

Here are some of the key benefits of Nitrosigine:

  • Enhanced Blood Flow: Nitrosigine has been shown to significantly increase nitric oxide levels, improving muscle flow during workouts. This can lead to better nutrient delivery and more pronounced muscle pumps. Research shows that Nitrosigine effectively increases blood flow and enhances exercise performance.

  • Improved Cognitive Function: Some studies suggest that Nitrosigine can enhance cognitive function, including focus and mental flexibility. This can be particularly beneficial during intense workouts where mental clarity and focus are crucial. This study shows that Nitrosigine can enhance cognitive function.

  • Increased Energy Levels: Nitrosigine can help to boost energy levels, making it a valuable ingredient in pre-workout supplements. This can lead to more productive workouts and improved performance. Research shows that Nitrosigine can enhance energy levels during workouts.

  • Potent at Smaller Doses: One of the key advantages of Nitrosigine is that it is effective at smaller doses compared to other similar supplements. This means you can experience the benefits without having to consume large amounts. 

Benefits of Citrulline

Citrulline, an amino acid converted into arginine in the body, also offers several benefits for regular physical activity.

Here are some of the key benefits of Citrulline:

  • Enhanced Exercise Performance: Citrulline has been shown to improve exercise performance by increasing ATP production, the body's primary energy source during workouts. Research shows that Citrulline can enhance exercise performance.

  • Improved Recovery: Citrulline can help to reduce muscle soreness and improve recovery after workouts. This can allow for more frequent and intense training sessions. This study shows that Citrulline can enhance recovery after workouts.

  • Boosted Nitric Oxide Production: Citrulline is converted into arginine in the body, which is then used to produce nitric oxide. Increased nitric oxide levels can lead to better blood flow and more pronounced muscle pumps. Research shows that Citrulline can enhance nitric oxide production.

  • Available in Several Forms: Citrulline is available in several forms, including L-Citrulline and Citrulline Malate, offering flexibility in how it can be consumed.

In conclusion, both Nitrosigine and Citrulline offer unique benefits and can be effective depending on your specific needs and preferences. It's important to consider these factors and consult with a healthcare professional before starting any new supplement.

Citrulline vs Nitrosigine: Which Is More Effective

When comparing Citrulline and Nitrosigine, it's clear that Nitrosigine is more potent at smaller doses.

This is due to Nitrosigine's unique ability to increase nitric oxide levels, improve blood flow, and enhance cognitive function.

However, Citrulline also has its benefits, but they are more pronounced at higher doses.

What's Better for Pumps

For muscle pumps, Nitrosigine may be the better choice. Its ability to increase nitric oxide levels and improve blood flow can produce more pronounced muscle pumps during workouts.

Research shows that Nitrosigine increases N.O. better than Citrulline, enhancing blood flow and muscle pumps.

What's Better for the Mind

When it comes to cognitive function, Nitrosigine also takes the lead. It has been shown to improve cognitive function, including focus and mental flexibility, which can be particularly beneficial during intense workouts.

This study shows that Nitrosigine can enhance cognitive function.

What's Better for Health

Both Nitrosigine and Citrulline have health benefits.

Nitrosigine has been shown to enhance blood flow, boost cognitive function, and increase energy levels, making it a valuable ingredient for overall health.

On the other hand, Citrulline also has health benefits, including enhancing exercise performance, improving recovery, and boosting nitric oxide production.

Who's It For, Who's It Not For

Nitrosigine is ideal for individuals who are looking for a potent pre-workout supplement that can enhance muscle pumps, increase energy levels, and improve cognitive function.

It's also suitable for those who prefer a supplement that is effective at smaller doses.

Citrulline, on the other hand, is suitable for individuals who are looking for a supplement that can enhance exercise performance and recovery.

It's also ideal for those who don't mind taking higher doses to achieve the desired effects.

Nitrosigine Pros and Cons

Pros

  • More potent at smaller doses
  • Enhances blood flow and muscle pumps
  • Boosts cognitive function
  • Increases energy levels

Cons

  • May not be as effective as Citrulline at higher doses
  • Some individuals may experience side effects such as stomach discomfort

Citrulline Pros and Cons

Pros

  • Enhances exercise performance and recovery
  • Boosts nitric oxide production
  • Available in several forms, including L-Citrulline and Citrulline Malate

Cons

  • Requires higher doses to achieve the desired effects
  • Some individuals may experience side effects such as stomach discomfort

Both Nitrosigine and Citrulline offer unique benefits and can be effective depending on your specific needs and preferences.

Nitrosigine is more potent at smaller doses and offers benefits such as enhanced blood flow, improved cognitive function, and increased energy levels.

Citrulline, on the other hand, is effective at enhancing exercise performance and recovery, and boosting nitric oxide production, but requires higher doses. It's important to consider these factors and consult with a healthcare professional before starting any new supplement regimen.

Which One is Better?

Determining which supplement is better depends on the individual's specific needs and goals. If the goal is to improve exercise performance and cardiovascular health, both supplements can be beneficial. However, if cognitive benefits are also desired, Nitrosigine may be the better choice.

Which One is Better for Pumps, Endurance, Performance, and Muscle Growth?

The research on which supplement is better for pumps, endurance, performance, and muscle growth is still ongoing.

Some studies suggest that both L-Citrulline and Nitrosigine can enhance exercise performance and muscle pump.

However, more research is needed to determine which one is more effective for endurance and muscle growth.

FAQ

What is Nitrosigine? Nitrosigine is a patented complex of arginine and silicon that has been shown to enhance blood flow, improve cognitive function, and boost energy levels. It is particularly effective in smaller doses.

What is Citrulline? Citrulline is an amino acid that is converted into arginine in the body. It is known for enhancing exercise performance, improving recovery, and boosting nitric oxide production.

Is Nitrosigine better than Citrulline? Both Nitrosigine and Citrulline have their unique benefits. Nitrosigine is more potent at smaller doses and offers cognitive benefits, while Citrulline is known for enhancing exercise performance and recovery. The choice between the two depends on your specific needs and preferences.

Can I take both Nitrosigine and Citrulline together? It's best to consult with a healthcare professional before combining supplements. While both Nitrosigine and Citrulline can offer benefits, they work in different ways and it's important to understand how they might interact.

What are the side effects of Nitrosigine and Citrulline? Both Nitrosigine and Citrulline are generally well-tolerated, but some individuals may experience side effects such as stomach discomfort. Always start with a smaller dose to assess tolerance.

How much Nitrosigine or Citrulline should I take? The optimal dosage can vary depending on individual needs and product formulation. It's always best to follow the manufacturer's instructions or consult with a healthcare professional.

When should I take Nitrosigine or Citrulline? Both Nitrosigine and Citrulline are often taken pre-workout to maximize their benefits. However, the timing can depend on individual preferences and product formulation.

Are Nitrosigine and Citrulline safe? Both Nitrosigine and Citrulline are generally considered safe for healthy individuals when used as directed. However, it's always best to consult with a healthcare professional before starting any new supplement regimen.

Can Nitrosigine and Citrulline improve muscle growth? While Nitrosigine and Citrulline can enhance exercise performance and recovery, indirectly supporting muscle growth, they are not directly muscle-building supplements.

Can I take Nitrosigine or Citrulline if I have a medical condition? If you have a medical condition or are taking medication, it's important to consult with a healthcare professional before starting any new supplement regimen, including Nitrosigine or Citrulline.

Bottom Line

L-Citrulline and Nitrosigine are effective supplements for enhancing nitric oxide production, improving blood flow, and boosting exercise performance.

However, they differ in their mechanisms of action, health benefits, and recommended dosages. L-Citrulline is beneficial for its role in the urea cycle and nitric oxide synthesis, while Nitrosigine enhances nitric oxide levels and is known for its cognitive benefits.

In a nutshell, both L-Citrulline and Nitrosigine are beneficial for exercise performance, but they offer different advantages and are used differently.

by Nader Qudimat

Forged by iron and cold steel, I'm Nader, a mid-30s natural bodybuilder. Once a 100lb skinny guy, I've transformed into a 200lb muscular athlete with over 15 years of lifting experience. Today, I leverage my transformation and extensive experience to guide countless individuals on their fitness journeys.

Click here to check out my 12 year transformation: Natural 12 Year Transformation

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